Document Detail

Morphological and immunohistochemical study of immediate contact dermatitis of the hands due to foods.
MedLine Citation:
PMID:  2138971     Owner:  NLM     Status:  MEDLINE    
This histological and immunohistochemical study of 6 food handlers affected by immediate contact dermatitis due to foods shows that apparently normal skin of patients with this condition presents several histological and immunohistochemical abnormalities. Skin biopsies of normal hand skin showed focal parakeratosis and moderately dense dermal infiltrates. Immunohistochemistry showed an increased number of Langerhans cells in the epidermis and in the superficial dermis and a mononuclear dermal infiltrate consisting of peripheral T lymphocytes with a CD4/CD8 ratio of 5-6/1. Biopsies of the immediate vesicular reactions induced by foods showed spongiotic vesicles within the epidermis and a moderate to dense mononuclear dermal perivascular infiltrate. The immunohistochemical features were similar to those described in apparently normal skin. The mechanism of this immediate vesicular reaction requires further research. The rapid appearance of the lesions (after 20-30 min) probably excludes an immunological cell-mediated pathogenesis. A non-immunological mechanism due to direct liberation of mediators by foods is more readily conceivable than an immediate immunological type of contact reaction.
A Tosti; P A Fanti; L Guerra; E Piancastelli; S Poggi; S Pileri
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contact dermatitis     Volume:  22     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1990 Feb 
Date Detail:
Created Date:  1990-05-24     Completed Date:  1990-05-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  81-5     Citation Subset:  IM    
Department of Dermatology, University of Bologna, Italy.
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MeSH Terms
Dermatitis, Contact / pathology*
Dermatitis, Occupational / pathology*
Food Handling*
Hand Dermatoses / pathology*
Patch Tests / methods
Skin / pathology

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