| Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies. | |
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MedLine Citation:
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PMID: 19486326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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INTRODUCTION: Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary. MATERIALS AND METHODS: We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma. RESULTS: The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma. CONCLUSION: PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer. |
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Authors:
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A Storstein; B K Krossnes; C A Vedeler |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta neurologica Scandinavica Volume: 120 ISSN: 1600-0404 ISO Abbreviation: Acta Neurol. Scand. Publication Date: 2009 Jul |
Date Detail:
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Created Date: 2009-06-16 Completed Date: 2009-08-28 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370336 Medline TA: Acta Neurol Scand Country: Denmark |
Other Details:
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Languages: eng Pagination: 64-7 Citation Subset: IM |
Affiliation:
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Department of Neurology, Haukeland University Hospital, Bergen, Norway. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenocarcinoma
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immunology,
pathology* Aged, 80 and over Autoantibodies / immunology* Female Gliosis / immunology, pathology Humans Immunohistochemistry Microglia / immunology, pathology Middle Aged Nerve Tissue Proteins / immunology* Ovarian Neoplasms / immunology, pathology* Paraneoplastic Cerebellar Degeneration / immunology, pathology* Purkinje Cells / immunology, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Autoantibodies; 0/CDR2 protein, human; 0/Nerve Tissue Proteins |
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