Document Detail


Morphological and immunohistochemical characterization of paraneoplastic cerebellar degeneration associated with Yo antibodies.
MedLine Citation:
PMID:  19486326     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
INTRODUCTION: Immunohistochemical studies of paraneoplastic cerebellar degeneration (PCD) are rare, and the findings vary. MATERIALS AND METHODS: We performed morphological and immunohistochemical characterization of the brain, medulla and tumour of two patients with PCD, Yo antibodies and ovarian adenocarcinoma. RESULTS: The cerebellum of both patients had extensive loss of Purkinje cells. Microglia activation and T cells were found in the cerebellum, but B cells or deposits of IgG or complement were not detected. Microglia activation was also present in the brain stem and medulla. T cells were found in the ovarian adenocarcinoma. CONCLUSION: PCD is characterized by loss of Purkinje cells and microglia activation, and the presence of T cells indicates cellular immune reactions in PCD and in ovarian cancer.
Authors:
A Storstein; B K Krossnes; C A Vedeler
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  120     ISSN:  1600-0404     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  2009 Jul 
Date Detail:
Created Date:  2009-06-16     Completed Date:  2009-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  64-7     Citation Subset:  IM    
Affiliation:
Department of Neurology, Haukeland University Hospital, Bergen, Norway.
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MeSH Terms
Descriptor/Qualifier:
Adenocarcinoma / immunology,  pathology*
Aged, 80 and over
Autoantibodies / immunology*
Female
Gliosis / immunology,  pathology
Humans
Immunohistochemistry
Microglia / immunology,  pathology
Middle Aged
Nerve Tissue Proteins / immunology*
Ovarian Neoplasms / immunology,  pathology*
Paraneoplastic Cerebellar Degeneration / immunology,  pathology*
Purkinje Cells / immunology,  pathology*
Chemical
Reg. No./Substance:
0/Autoantibodies; 0/CDR2 protein, human; 0/Nerve Tissue Proteins

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