Document Detail


Morphological and histochemical study of nonhemiplegic muscle in acute stroke patients manifesting respiratory failure.
MedLine Citation:
PMID:  8719644     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
There is little information on skeletal muscle changes in patients with acute stroke. We performed morphological and histochemical examinations of nonhemiplegic sternothyroid muscles biopsied at the time of tracheostomy from 13 patients with acute stroke manifesting acute respiratory failure. Degenerating and regenerating fibers were observed in all 13 specimens. Following characteristic myopathic changes suggestive of mitochondrial abnormalities were also demonstrated in a majority of patients. Namely, ragged-red fibers, focal increase in NADH-TR activity in subsarcolemmal areas and increases in acid phosphate activity were found. The changes were similar but extremely slight in control patients with acute respiratory failure due to causes other than stroke and were absent in the other control patients with adenomatous thyroid tumor. The severity and extent of the histopathological changes in the muscle fibers in patients with acute stroke were closely correlated with the duration of hypoxemia but not with such items as type of stroke, site of cerebral lesion, consciousness level, days of biopsy after the stroke, clinical outcome, levels of serum creatine kinase, myoglobin and PaO2. This acute nonhemiplegic muscle involvement was considered to be a very common complication in severe stroke patients.
Authors:
Y Sato; Y Honda; K Oizumi; N Kaku; H Furuno; Y Ohta; S Ito; I Higuchi; M Osame
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  European neurology     Volume:  36     ISSN:  0014-3022     ISO Abbreviation:  Eur. Neurol.     Publication Date:  1996  
Date Detail:
Created Date:  1996-11-22     Completed Date:  1996-11-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Affiliation:
First Department of Internal Medicine, Kurume University School of Medicine, Japan.
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Adenosine Triphosphatases / analysis*
Aged
Cerebrovascular Disorders / complications*
Creatine Kinase / blood
Female
Humans
Male
Middle Aged
Muscle, Skeletal / chemistry*,  physiopathology
Myoglobin / blood
Respiratory Insufficiency / etiology*
Thioredoxin-Disulfide Reductase / analysis*
Chemical
Reg. No./Substance:
0/Myoglobin; EC 1.8.1.9/Thioredoxin-Disulfide Reductase; EC 2.7.3.2/Creatine Kinase; EC 3.6.1.-/Adenosine Triphosphatases

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