| Morphological and hemodynamic magnetic resonance assessment of early neonatal brain injury in a piglet model. | |
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MedLine Citation:
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PMID: 15221803 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To investigate the utility of functional and morphological magnetic resonance imaging (MRI) to assess the extent of brain injury in a hypoxia-ischemia (HI) piglet model and further to validate that the desired ischemic injury was successfully induced. MATERIALS AND METHODS: MRI was performed at 1.5 T in anesthetized piglets (N = 10, age = 12-36 hours). Relative cerebral blood flow (rCBF), time-to-peak (TTP) contrast, and apparent diffusion coefficient (ADC) were estimated at different time points pre-, during, and post-HI. The effect following bilateral clamping of the carotid arteries was assessed by contrast-enhanced MR angiography (MRA) and phase contrast MR angiography (PCA) (N = 4). RESULTS: A linear correlation was observed between relative cerebral perfusion reduction and cerebral ADC during HI (r(2) = 0.85, P < 0.05). There was no correlation between rCBF reduction during 30 minutes of HI and cerebral ADC after 30 or 150 minutes of reperfusion/reoxygenation (RR). CONCLUSION: The combination of morphological and functional (perfusion and diffusion) MRI enabled consistent assessment of both the presence and absence of complete occlusion as well as the functional significance of the occlusion. |
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Authors:
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Berit H Munkeby; Kristin Lyng; Jahn Frederik Frøen; Eldrid H Winther-Larssen; Jan Henrik Rosland; Hans-Jørgen Smith; Ola Didrik Saugstad; Atle Bjørnerud |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of magnetic resonance imaging : JMRI Volume: 20 ISSN: 1053-1807 ISO Abbreviation: J Magn Reson Imaging Publication Date: 2004 Jul |
Date Detail:
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Created Date: 2004-06-28 Completed Date: 2004-09-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9105850 Medline TA: J Magn Reson Imaging Country: United States |
Other Details:
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Languages: eng Pagination: 8-15 Citation Subset: IM |
Copyright Information:
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Copyright 2004 Wiley-Liss, Inc. |
Affiliation:
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Department of Pediatric Research, Rikshospitalet University Hospital, Oslo, Norway. b.h.munkeby@klinmed.uio.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Animals, Newborn Blood Flow Velocity Cerebrovascular Circulation* Diffusion Magnetic Resonance Imaging Hypoxia-Ischemia, Brain / diagnosis*, physiopathology Image Processing, Computer-Assisted Magnetic Resonance Angiography Magnetic Resonance Imaging* Swine |
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