Document Detail

Morphological and functional evaluation of the pancreatic duct with secretin-stimulated magnetic resonance cholangiopancreatography in alcoholic pancreatitis patients.
MedLine Citation:
PMID:  18470615     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this investigation was to evaluate the pancreatographic findings and dynamics of pancreatic duct diameter, as determined by secretin-enhanced magnetic resonance cholangiopancreatography (S-MRCP), in patients with acute alcoholic pancreatitis or chronic alcoholic pancreatitis and in a control group. METHODS: S-MRCP was performed in patients with acute alcoholic pancreatitis who did not manifest the functional and radiological (ultrasonography and computed tomography) criteria of chronic pancreatitis (n = 21), in patients with chronic alcoholic pancreatitis (n = 28) and in a control group (n = 16). The diameter of the main pancreatic duct (MPD) was monitored before secretin administration and at 3 and 10 min after secretin administration. Morphological features were also assessed before and after the administration of secretin. RESULTS: All ductal diameters were significantly larger in chronic alcoholic pancreatitis (P < 0.0001). There were no differences in MPD caliber between patients with acute alcoholic pancreatitis and the control group. The percentage of variation between basal MPD diameter and at 3 min post-secretin administration was lower in patients with chronic (35.5%) pancreatitis than in those with acute alcoholic pancreatitis (52.3%) and the control group (52.5%). There were no significant differences between patients with acute alcoholic pancreatitis and the control group in terms of the frequency of visualization of side branches, ductal narrowing, intraluminal filling defects, and ductal irregularity. One patient with acute alcoholic pancreatitis presented ductal criteria of chronic pancreatitis following the administration of secretin. CONCLUSIONS: The dynamics of MPD visualized on S-MRCP in patients with acute alcoholic pancreatitis is similar to that observed in the control group and different from that observed in patients with chronic alcoholic pancreatitis. There were no significant differences between patients with acute alcoholic pancreatitis and the control group in terms of morphological pancreatographic features.
Isabel Pascual; José Soler; Andrés Peña; Ramón Añón; Pedro Almela; Vicente Sánchiz; Miguel Mínguez; Francisco Mora; Adolfo Benages
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Publication Detail:
Type:  Evaluation Studies; Journal Article     Date:  2008-05-10
Journal Detail:
Title:  Digestive diseases and sciences     Volume:  53     ISSN:  0163-2116     ISO Abbreviation:  Dig. Dis. Sci.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-11-12     Completed Date:  2009-02-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7902782     Medline TA:  Dig Dis Sci     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3234-41     Citation Subset:  AIM; IM    
Department of Gastroenterology, University Clinic Hospital of Valencia, University of Valencia, Avda Blasco Ibañez 17, Valencia, 46010, Spain.
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MeSH Terms
Acute Disease
Case-Control Studies
Cholangiopancreatography, Magnetic Resonance*
Chronic Disease
Diagnosis, Differential
Gastrointestinal Agents / pharmacology*
Middle Aged
Pancreatic Ducts / drug effects,  pathology*,  physiopathology*
Pancreatitis, Alcoholic / diagnosis,  pathology*,  physiopathology*
Secretin / pharmacology*
Time Factors
Reg. No./Substance:
0/Gastrointestinal Agents; 1393-25-5/Secretin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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