| Morphological evidence of neurotoxicity in retina after methylmercury exposure. | |
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MedLine Citation:
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PMID: 22531226 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The visual system is particularly sensitive to methylmercury (MeHg) exposure and, therefore, provides a useful model for investigating the fundamental mechanisms that direct toxic effects. During a period of 70 days, adult of a freshwater fish species Hoplias malabaricus were fed with fish prey previously labeled with two different doses of methylmercury (0.075 and 0.75μgg(-1)) to determine the mercury distribution and morphological changes in the retina. Mercury deposits were found in the photoreceptor layer, in the inner plexiform layer and in the outer plexiform layer, demonstrating a dose-dependent bioaccumulation. The ultrastructure analysis of retina revealed a cellular deterioration in the photoreceptor layer, morphological changes in the inner and outer segments of rods, structural changes in the plasma membrane of rods and double cones, changes in the process of removal of membranous discs and a structural discontinuity. These results lead to the conclusion that methylmercury is able to cross the blood-retina barrier, accumulate in the cells and layers of retina and induce changes in photoreceptors of H. malabaricus even under subchronic exposure. |
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Authors:
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Maritana Mela; Sonia Regina Grötzner; Alexia Legeay; Nathalie Mesmer-Dudons; Jean-Charles Massabuau; Dora Fix Ventura; Ciro Alberto de Oliveira Ribeiro |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-17 |
Journal Detail:
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Title: Neurotoxicology Volume: - ISSN: 1872-9711 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-25 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7905589 Medline TA: Neurotoxicology Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012. Published by Elsevier B.V. |
Affiliation:
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Departamento de Psicologia Experimental, Instituto de Psicologia, Universidade de São Paulo, São Paulo, SP, Brazil; Núcleo de Apoio à Pesquisa em Neurociência e Comportamento, Universidade de São Paulo, São Paulo, SP, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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