Document Detail

Morphological detection and quantification of lipoprotein(a) deposition in atheromatous lesions of human aorta and coronary arteries.
MedLine Citation:
PMID:  2142355     Owner:  NLM     Status:  MEDLINE    
Lipoprotein(a), as an atherogenic particle, represents an independent risk factor for coronary heart disease. In the present study the morphological distribution of apoprotein (a) and apoprotein B within the arterial wall is described. Apoprotein B, a constituent of very low-density lipoprotein, low-density lipoprotein and lipoprotein(a) has previously been demonstrated in atheromatous lesions. Lipoprotein(a) possesses an additional protein, designated apoprotein (a). Autopsy material (n = 74) from the left coronary artery and from the thoracic aorta has been examined by means of immunohistochemistry and both apoprotein (a) and apoprotein B were detected, primarily associated with the extracellular matrix and accumulating in lesions in the arterial wall. The staining pattern for both antigens was almost always found to be congruent, suggesting that the detection of (a)-antigen has to be attributed at least in part to the presence of lipoprotein(a). It is concluded that both low-density lipoprotein and lipoprotein(a) have an important role in the pathogenesis of atherosclerosis.
A Niendorf; M Rath; K Wolf; S Peters; H Arps; U Beisiegel; M Dietel
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Virchows Archiv. A, Pathological anatomy and histopathology     Volume:  417     ISSN:  0174-7398     ISO Abbreviation:  Virchows Arch A Pathol Anat Histopathol     Publication Date:  1990  
Date Detail:
Created Date:  1990-08-16     Completed Date:  1990-08-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8302198     Medline TA:  Virchows Arch A Pathol Anat Histopathol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  105-11     Citation Subset:  IM    
Institut für Pathologie, Universität Hamburg, Federal Republic of Germany.
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MeSH Terms
Aged, 80 and over
Aorta / metabolism,  pathology
Aortic Diseases / metabolism*,  pathology
Apolipoproteins A / metabolism
Apolipoproteins B / metabolism
Arteriosclerosis / metabolism*,  pathology
Child, Preschool
Coronary Disease / metabolism*,  pathology
Coronary Vessels / metabolism,  pathology
Infant, Newborn
Lipoproteins / metabolism*
Middle Aged
Tissue Distribution
Reg. No./Substance:
0/Apolipoproteins A; 0/Apolipoproteins B; 0/Lipoprotein(a); 0/Lipoproteins
Erratum In:
Virchows Arch A Pathol Anat Histopathol 1991;418(1):86

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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