Document Detail

Morphological descriptors as rupture indicators in middle cerebral artery aneurysms.
MedLine Citation:
PMID:  21097120     Owner:  NLM     Status:  MEDLINE    
The rupture of intracranial aneurysms is associated to significant morbidity and mortality rates. Although the mechanisms triggering this event are still unclear, morphology is among the factors considered by interventional neuroradiologists to decide treatment. The aim of this work is to explore the potential of morphological descriptors as rupture risk predictors in middle cerebral artery aneurysms (MCA) and to provide the subset showing the best predictive capabilities. The set of evaluated descriptors include basic shape descriptors related to the aneurysm size, and most sophisticated ones such as the Zernike Moment Invariants. The population analyzed included 71 patients harboring 86 MCA aneurysms (64 unruptured vs. 22 ruptured). An existing image-based processing pipeline was used to extract such descriptors from Three-Dimensional Rotational Angiography (3DRA) images routinely acquired during standard clinical practice. Univariate and multivariate statistical analyses have shown that among the evaluated descriptors, Zernike moment invariants computed on the aneurysm and a small portion of the surrounding vessels, together with the non-sphericity index, provide the best predictive capabilities of aneurysm rupture.
C Valencia; M C Villa-Uriol; J M Pozo; A F Frangi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference     Volume:  2010     ISSN:  1557-170X     ISO Abbreviation:  Conf Proc IEEE Eng Med Biol Soc     Publication Date:  2010  
Date Detail:
Created Date:  2010-11-24     Completed Date:  2011-03-11     Revised Date:  2014-08-21    
Medline Journal Info:
Nlm Unique ID:  101243413     Medline TA:  Conf Proc IEEE Eng Med Biol Soc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6046-9     Citation Subset:  IM    
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MeSH Terms
Aneurysm, Ruptured / diagnosis*,  pathology*
Discriminant Analysis
Intracranial Aneurysm / diagnosis*,  pathology*
Middle Aged
Models, Biological
Multivariate Analysis
ROC Curve

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