Document Detail

Morphological correlates of acute and permanent hearing loss during experimental pneumococcal meningitis.
MedLine Citation:
PMID:  12744466     Owner:  NLM     Status:  MEDLINE    
In patients with acute bacterial meningitis, hearing loss can be transient but is often permanent. The mechanisms underlying meningitis-associated hearing loss are not fully understood. Therefore, we investigated the morphological correlates of hearing loss in a rat model of pneumococcal meningitis. Transcutaneous intracisternal injection of Streptococcus pneumoniae resulted in a dose-dependent hearing loss (determined by auditory brainstem response audiometry), which was partially reversible during the acute stage. Nevertheless, a severe permanent hearing loss persisted until 2 weeks after infection. Suppurative labyrinthitis was accompanied by blood-labyrinth barrier disruption (determined by cochlear Evans blue extravasation), which correlated closely with hearing loss during the acute stage but not after recovery. Two weeks after infection, spiral ganglion neuronal density was markedly decreased and correlated with the severity of permanent hearing loss. Neuronal loss can be explained by the new finding of meningitis-associated spiral ganglion neuronal necrosis rather than apoptosis (determined by morphology, TUNEL staining, and immunohistochemistry).
Matthias Klein; Uwe Koedel; Hans-Walter Pfister; Stefan Kastenbauer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brain pathology (Zurich, Switzerland)     Volume:  13     ISSN:  1015-6305     ISO Abbreviation:  Brain Pathol.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-14     Completed Date:  2003-06-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9216781     Medline TA:  Brain Pathol     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  123-32     Citation Subset:  IM    
Department of Neurology, Klinikum Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
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MeSH Terms
Capillary Permeability
Cell Death
Cochlea / pathology*
Disease Models, Animal
Ear, Inner / blood supply,  pathology
Hearing Loss, Central / etiology,  pathology*
In Situ Nick-End Labeling
Labyrinthitis / complications,  pathology
Meningitis, Pneumococcal / complications,  pathology*
Neurons / pathology
Rats, Wistar
Spiral Ganglion / pathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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