Document Detail

Morphological characteristics of tendon cells cultured on synthetic fibers.
MedLine Citation:
PMID:  6242476     Owner:  NLM     Status:  MEDLINE    
Filamentous carbon is currently being used as an implant material for tendon and ligament repair in humans. This material acts as a scaffold for the organization of new fibrous tissue growth. Primary cultures of rat tendon fibroblast cells (1 degrees RTF cells) were grown on carbon, Dacron, polyethylene and Nylon fibers in vitro. The morphological characteristics of these cells were examined. The process of cell migration from tendon explant to fiber substrate was similar for all four materials. Three morphological categories of cells were observed on these materials. (1) spherical dividing cells, (2) spindle-shaped migrating cells, (3) sheath-like migrating or stationary cells. The morphological characteristics and orientational behavior of cultured fibroblasts on these fiber materials were strongly influenced by the diameters of the fibers and by fiber surface characteristics such as longitudinal striations. The possible mechanisms of cell response to substrate geometric configuration are discussed along with the clinical significance of these experiments.
J L Ricci; A G Gona; H Alexander; J R Parsons
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  18     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:    1984 Nov-Dec
Date Detail:
Created Date:  1985-12-30     Completed Date:  1985-12-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1073-87     Citation Subset:  IM    
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MeSH Terms
Cells, Cultured
Microscopy, Electron, Scanning
Polyethylene Terephthalates
Rats, Inbred Strains
Tendons / cytology*
Reg. No./Substance:
0/Nylons; 0/Polyethylene Terephthalates; 0/Polyethylenes; 7440-44-0/Carbon

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