| Morphological characteristics of tendon cells cultured on synthetic fibers. | |
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MedLine Citation:
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PMID: 6242476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Filamentous carbon is currently being used as an implant material for tendon and ligament repair in humans. This material acts as a scaffold for the organization of new fibrous tissue growth. Primary cultures of rat tendon fibroblast cells (1 degrees RTF cells) were grown on carbon, Dacron, polyethylene and Nylon fibers in vitro. The morphological characteristics of these cells were examined. The process of cell migration from tendon explant to fiber substrate was similar for all four materials. Three morphological categories of cells were observed on these materials. (1) spherical dividing cells, (2) spindle-shaped migrating cells, (3) sheath-like migrating or stationary cells. The morphological characteristics and orientational behavior of cultured fibroblasts on these fiber materials were strongly influenced by the diameters of the fibers and by fiber surface characteristics such as longitudinal striations. The possible mechanisms of cell response to substrate geometric configuration are discussed along with the clinical significance of these experiments. |
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Authors:
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J L Ricci; A G Gona; H Alexander; J R Parsons |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Journal of biomedical materials research Volume: 18 ISSN: 0021-9304 ISO Abbreviation: J. Biomed. Mater. Res. Publication Date: 1984 Nov-Dec |
Date Detail:
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Created Date: 1985-12-30 Completed Date: 1985-12-30 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0112726 Medline TA: J Biomed Mater Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1073-87 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Carbon Cells, Cultured Humans Male Microscopy, Electron, Scanning Nylons Polyethylene Terephthalates Polyethylenes Rats Rats, Inbred Strains Tendons / cytology* |
| Chemical | |
Reg. No./Substance:
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0/Nylons; 0/Polyethylene Terephthalates; 0/Polyethylenes; 7440-44-0/Carbon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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