| Morphological changes of the rat intestinal lining in relation to body stores depletion during fasting and after refeeding. | |
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MedLine Citation:
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PMID: 17638014 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intestinal villus atrophy through prolonged fasting was studied according to two different metabolic phases reached by fasting animals and characterized by (a) the mobilization of fat stores as body fuel and (b) an increase in protein catabolism for energy expenditure. The mechanisms involved in the rapid jejunal restoration after refeeding were also determined. Mucosal structural atrophy during fasting proved to worsen over the two phases due mainly to the retraction of the lacteals in the lamina propria, as observed through the immunolocalization of aquaporin 1 in the endothelial cells of the lymphatic vessels and the detachment of the basal membrane of the epithelial lining at the tip of the villi. Microvilli surface area is preserved through fasting, and apical PepT1 expression increases during both metabolic fasting phases. Refeeding after both fasting phases induces an increase in FATP4 accompanied by a rapid lipid uptake by the enterocytes at the tip of the villi and a rapid extension of the lamina propria due to inflated lymphatic vessels. These mechanisms were more prevalent in animals refed after the phase III fast and could be considered as the major processes allowing complete morphological restoration of the jejunum within only 3 days after refeeding. |
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Authors:
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Caroline Habold; François Reichardt; Charlotte Foltzer-Jourdainne; Jean-Hervé Lignot |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-07-19 |
Journal Detail:
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Title: Pflügers Archiv : European journal of physiology Volume: 455 ISSN: 0031-6768 ISO Abbreviation: Pflugers Arch. Publication Date: 2007 Nov |
Date Detail:
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Created Date: 2007-10-05 Completed Date: 2008-06-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0154720 Medline TA: Pflugers Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 323-32 Citation Subset: IM |
Affiliation:
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Département d'Ecologie, Physiologie et Ethologie, CNRS, IPHC, 23 rue Becquerel, 67087 Strasbourg cedex 2, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / physiology Aquaporin 1 / metabolism Atrophy / metabolism, pathology Eating / physiology* Energy Metabolism / physiology* Fasting / physiology* Fatty Acid Transport Proteins / metabolism Intestinal Mucosa / metabolism, pathology*, ultrastructure Lipid Metabolism / physiology Male Microvilli / metabolism, pathology, ultrastructure Rats Rats, Wistar Symporters / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Fatty Acid Transport Proteins; 0/Slc15a1 protein, rat; 0/Symporters; 146410-94-8/Aquaporin 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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