Document Detail

Morphological changes positive correlates with oxidative stress in COPD. Preliminary data of an experimental rat model--study and literature review.
MedLine Citation:
PMID:  17502953     Owner:  NLM     Status:  MEDLINE    
It is well known that nicotine that is a major toxic component of cigarette smoke induces oxidative stress which is responsible for the lung damages in COPD and cancer. There have been reported some cases of COPD in never smoking patients exposed to air pollutants. The aim of our study is to evaluate the morphological pulmonary changes in rats exposed to cigarette smoke respectively to solid combustible smoke and to establish the relationship between the exposure and the level of oxidative stress measured through serum (s) and pulmonary tissue (l) MDA in rats (TBARS method). Thirty Wistar rats were divided into three groups (n = 10): (1) the control group (C), (2) the cigarette smoke group (CS), and (3) the solid combustible smoke group (SC). Apart from the control group, these were treated with solid combustibles smoke or cigarette smoke for six months. We collected blood for serum determination of MDA and the lungs were removed for histopathological analysis and to determine the levels of malondialdehyde (MDA). The levels of serum and lung MDA were significantly higher in CS and SC groups compared with C group, but not significantly differences between CS and SC group were detected. These findings are positively correlated with histopathological changes (squamous metaplasia and clear cell hyperplasia in the bronchium epithelium, emphysema) found in pulmonary tissue. Preliminary data of our study confirms that not only the cigarette smoke but also the environmental pollutants are involved in the major pathways of COPD.
Elena Doina Murărescu; Roxana Iancu; Maria Sultana Mihailovici
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie     Volume:  48     ISSN:  1220-0522     ISO Abbreviation:  Rom J Morphol Embryol     Publication Date:  2007  
Date Detail:
Created Date:  2007-05-15     Completed Date:  2007-07-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9112454     Medline TA:  Rom J Morphol Embryol     Country:  Romania    
Other Details:
Languages:  eng     Pagination:  59-65     Citation Subset:  IM    
Department of Pathology, Gr. T. Popa University of Medicine and Pharmacy, Iassy, Romania.
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MeSH Terms
Air Pollutants / toxicity*
Malondialdehyde / blood
Oxidative Stress*
Pulmonary Disease, Chronic Obstructive / metabolism,  pathology*
Pulmonary Emphysema / pathology
Rats, Wistar
Respiratory Mucosa / metabolism,  pathology
Smoking / adverse effects*
Reg. No./Substance:
0/Air Pollutants; 542-78-9/Malondialdehyde

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