| Morphological changes and morphological-functional correlations in acute experimental ischemia/reperfusion pancreatitis in rats. | |
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MedLine Citation:
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PMID: 11247388 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The etiology of acute pancreatitis, apart from alcohol abuse and cholelithiasis may also include a vascular component responsible for pancreatic ischemia. It is now acknowledged that chronic pancreatitis may be a consequence of the acute variant, but it remains unclear what factors influence this sequence of morphological changes. In order to clarify this issue we proposed a model of experimental acute pancreatitis in rats induced by a 30 min reduction of blood flow in inferior splenic artery followed by reperfusion. Rats were sacrificed at 1 h, 12 h, 24 h, and 2, 3, 5, 7, 14, 21, 28 days after cessation of ischemia. We performed histopathological examination of pancreatic tissue and measured pancreatic blood flow, plasma amylase activity and interleukin-1 beta concentration. The present findings indicate that transient pancreatic ischemia leads to the development of acute necro-haemorrhagic pancreatitis. The morphological features of acute inflammation are correlated positively with functional disorders. In some cases the features of chronic pancreatitis may appear transiently after the acute phase, whereas the repair of postinflammatory injury involves the regeneration of acinar cells. |
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Authors:
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R Tomaszewska; A Dembiński; Z Warzecha; P Ceranowicz; J Stachura |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Polish journal of pathology : official journal of the Polish Society of Pathologists Volume: 51 ISSN: 1233-9687 ISO Abbreviation: Pol J Pathol Publication Date: 2000 |
Date Detail:
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Created Date: 2001-03-14 Completed Date: 2001-04-12 Revised Date: 2007-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9437432 Medline TA: Pol J Pathol Country: Poland |
Other Details:
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Languages: eng Pagination: 179-84 Citation Subset: IM |
Affiliation:
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Department of Clinical and Experimental Pathomorphology, Jagiellonian University Medical College, Kraków. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Amylases / blood Animals Interleukin-1 / blood Ischemia / blood, pathology Male Pancreas / blood supply, enzymology Pancreatitis / blood, pathology* Rats Rats, Wistar Regional Blood Flow Reperfusion Injury / blood, pathology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-1; EC 3.2.1.-/Amylases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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