Document Detail


Morphological changes of intracranial pressure pulses are correlated with acute dilatation of ventricles.
MedLine Citation:
PMID:  19388304     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Potentially useful information may exist in the morphological changes in intracranial pressure pulse therefore their extraction by automated methods is highly desirable. METHODS: Long-term continuous recordings of intracranial pressure and electrocardiogram (ECG) signals were analyzed for four patients undergoing intracranial pressure (ICP) monitoring with their implanted shunts externalized and clamped. A novel clustering algorithm was invented to process hours of continuous ICP recordings such that a dominant ICP pulse was extracted every 5 min. Morphological characteristics of dominant ICP pulses were then extracted after detecting characteristics points of a dominant ICP pulse that include the locations of ICP pulse onset, the first (P1), the second (P2), and the third peaks (P3) (or inflection points in the absence of peaks). FINDINGS: It was found that ratios of P2 amplitude to P1 amplitude and P3 amplitude to P1 amplitude showed a strong increasing trend for a patient whose lateral ventricles were significantly enlarged (bi-frontal distance was 33 cm on day 0 and 37 cm on day 2) while there were no consistent trends in these morphological features of ICP pulse for the three patients whose ventricles size was not altered during the monitoring period. CONCLUSION: The present work demonstrates the usefulness of this novel ICP pulse analysis algorithm in terms of its potential capabilities of extracting predictive pulse morphological features from long-term continuous ICP recordings that correlate with the development of ventriculomegaly.
Authors:
Xiao Hu; Peng Xu; Darrin J Lee; Vespa Paul; Marvin Bergsneider
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Acta neurochirurgica. Supplement     Volume:  102     ISSN:  0065-1419     ISO Abbreviation:  Acta Neurochir. Suppl.     Publication Date:  2008  
Date Detail:
Created Date:  2009-04-24     Completed Date:  2009-06-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100962752     Medline TA:  Acta Neurochir Suppl     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  131-6     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, The David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Algorithms
Dilatation, Pathologic / pathology*
Electrocardiography / methods
Female
Heart Ventricles / pathology*
Humans
Intracranial Pressure / physiology*
Middle Aged
Monitoring, Physiologic
Pulse
Reaction Time
Signal Processing, Computer-Assisted
Time Factors
Grant Support
ID/Acronym/Agency:
R01 NS054881/NS/NINDS NIH HHS; R21 NS055045/NS/NINDS NIH HHS; R21 NS055998/NS/NINDS NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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