Document Detail

Morphological changes in prostatic adenomas after transurethral microwave thermotherapy.
MedLine Citation:
PMID:  9240191     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the extension and type of tissue damage in prostatic adenomas after transurethral microwave thermotherapy (TUMT). PATIENTS AND METHODS: Seven patients with benign prostatic hyperplasia and scheduled for open adenectomy underwent TUMT before surgery. TUMT was performed 2 h before operation in one patient, 24 h before in five and one week before in the remaining patient. The excised adenomas were examined by routine light microscopy. In addition, the terminal deoxynucleotidyl nick-end labelling (TUNEL) technique was used to search for DNA-strand breaks in areas with morphological alterations suggestive of apoptosis. Due to technical problems, TUMT was inadequate for one patient, i.e. the effect given was extremely low. RESULTS: In six cases, histopathological changes were found in limited areas extending from the urethra for 20-25 mm into the prostatic tissue. The predominant histopathological findings were areas of necrosis surrounded by cells with apoptotic features. The latter proved to be TUNEL-positive, i.e. they contained nuclei with DNA fragmentation of the apoptotic type. In the case with inadequate TUMT, there was no heat-induced tissue damage. CONCLUSION: The area of tissue damage seen after TUMT was relatively small compared with the volume of the prostates. The main histopathological finding was massive necrosis, but cells undergoing apoptosis were also identified. Obviously, temperatures lower than those leading to necrosis induced apoptosis, which is a discrete type of cell death not associated with oedema or inflammatory reaction.
M Brehmer
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of urology     Volume:  80     ISSN:  0007-1331     ISO Abbreviation:  Br J Urol     Publication Date:  1997 Jul 
Date Detail:
Created Date:  1997-08-22     Completed Date:  1997-08-22     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  15740090R     Medline TA:  Br J Urol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  123-7     Citation Subset:  IM    
Department of Urology, South Hospital, Stockholm, Sweden.
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MeSH Terms
Hyperthermia, Induced / methods*
Microwaves / therapeutic use*
Postoperative Care
Prostatic Hyperplasia / pathology,  therapy*

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