Document Detail

Morphological changes in disc herniation in the lower cervical spine: an ultrastructural study.
MedLine Citation:
PMID:  22407261     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: The basis of disc degeneration is still unknown, but is believed to be a cell-mediated process. Apoptosis might play a major role in degenerative disc disease (DDD). The aim of this study was to correlate the viability of disc cells with the radiological degeneration grades (rDG) in disc herniation.
MATERIALS AND METHODS: Forty anterior IVD's (C4-C7) from 39 patients with DDD were studied histologically and ultrastructurally to quantify healthy, "balloon", chondroptotic, apoptotic and necrotic cells. Patients were classified to their rDG, as having either prolapse (P: DGII + III) and/or osteochondrosis (O: DGIV + V). Similar studies were undertaken on eight control discs.
RESULTS: Cell death by necrosis (mean 35%) was common but differed not significantly in both groups. All patients with a disc prolapse DGII + III revealed balloon cells (iAF: mean 32%). All appeared alive and sometimes were hypertrophic. However, significantly less balloon cells were found in the O-Group. Control samples revealed no evidence of "balloon" cells in DGII and only a minor rate in DGIII.
CONCLUSION: According to the different rDG, quantitative changes were obvious in healthy and "balloon" cells, but not for cell death. At the moment it can only be hypothesized if "balloon" cells are part of a repair strategy and/or cause of disc herniation.
Ingrid Sitte; Anton Kathrein; Florian Pedross; Martin C Freund; Kristian Pfaller; Charles W Archer
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2012-03-10
Journal Detail:
Title:  European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society     Volume:  21     ISSN:  1432-0932     ISO Abbreviation:  Eur Spine J     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-04     Completed Date:  2013-01-02     Revised Date:  2013-07-02    
Medline Journal Info:
Nlm Unique ID:  9301980     Medline TA:  Eur Spine J     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1396-409     Citation Subset:  IM    
Department of Traumatology, Medical University of Innsbruck, Anichstr 35, 6020 Innsbruck, Austria.
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MeSH Terms
Case-Control Studies
Cell Survival
Cervical Vertebrae / pathology*,  radiography,  ultrastructure*
Intervertebral Disc / pathology*,  radiography,  ultrastructure*
Intervertebral Disc Degeneration / pathology*,  radiography
Intervertebral Disc Displacement / pathology*,  radiography
Magnetic Resonance Imaging
Middle Aged
Tomography, X-Ray Computed

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