| Morphological changes in adrenals from victims of suicide in relation to altered apoptosis. | |
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MedLine Citation:
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PMID: 9888607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Endocrine dysfunction may cause psychiatric symptoms and, vice versa, psychiatric diseases may lead to endocrine alterations. The adrenal as the end organ of both the hypothalamic-pituitary-adrenocortical and sympatho-adrenal axes is subject to the functional changes of the stress system. Thus, increased adrenal gland weight was observed previously in victims of violent suicide. This study was designed to analyze the morphological and morphodynamic changes of adrenals from suicide victims. We investigated 30 adrenals obtained from 15 suicide victims using immunohistochemistry and a computerized video system. In addition, apoptosis and cell proliferation were analyzed. We found a significant enlargement of the adrenal cortex to 158.8% (SD = 29.8%, p < 0.01) that was restricted to the two inner zones only (zona reticularis, 161.6 +/- 35.3%; zona fasciculata, 186.4 +/- 34.4%). This increase in adrenocortical size correlated with a decrease in the number of apoptotic cells within the zona fasciculata. In conclusion, these results clearly demonstrate chronic structural adrenal changes in suicide victims. The adrenal gland mirrors the functional changes of the stress system which leaves an imprint on the morphology of the gland. |
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Authors:
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H S Willenberg; S R Bornstein; T Dumser; M Ehrhart-Bornstein; A Barocka; G P Chrousos; W A Scherbaum |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Endocrine research Volume: 24 ISSN: 0743-5800 ISO Abbreviation: Endocr. Res. Publication Date: 1998 Aug-Nov |
Date Detail:
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Created Date: 1999-04-13 Completed Date: 1999-04-13 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8408548 Medline TA: Endocr Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 963-7 Citation Subset: IM |
Affiliation:
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Diabetes Research Institute, University of Duesseldorf, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adrenal Glands
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pathology* Apoptosis* Cadaver Cell Division Computers Humans Immunohistochemistry In Situ Nick-End Labeling Suicide* Television Zona Fasciculata / pathology Zona Reticularis / pathology |
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