Document Detail

Morphological changes due to Lead exposure and the influence of DMSA on the gill tissues of the freshwater fish, Catla catla.
MedLine Citation:
PMID:  18468759     Owner:  NLM     Status:  MEDLINE    
Catla catla fingerlings were reared in freshwater and exposed to 15.5 ppm concentration of lead for 60 days. The morphological changes on the gill of the C. catla fingerlings due to lead intoxication and the effect of DMSA (meso 2,3-dimercaptosuccinic acid) on the affected tissues were observed using Scanning Electron Microscope. It has been found that the lead treated gill tissues showed certain marked changes, such as cell hypertrophy, alteration in the lamellar surfaces, epithelial hyperplasia and the fusion of adjacent lamellae. The antidote DMSA treatment reduces the toxic effects and helps the recovery of gill tissue and its return to the level of the control/normal.
P L R M Palaniappan; Selvi Sabhanayakam; N Krishnakumar; M Vadivelu
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Publication Detail:
Type:  Journal Article     Date:  2008-04-04
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  46     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-10     Completed Date:  2008-08-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  2440-4     Citation Subset:  IM    
Department of Physics, Annamalai University, Annamalai Nagar 608 002, Tamilnadu, India.
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MeSH Terms
Antidotes / pharmacology*
Cyprinidae / metabolism*
Environmental Exposure
Fresh Water
Gills / drug effects*,  pathology,  ultrastructure
Lead / antagonists & inhibitors*,  toxicity*
Microscopy, Electron, Scanning / methods,  veterinary
Succimer / pharmacology*
Time Factors
Reg. No./Substance:
0/Antidotes; 304-55-2/Succimer; 7439-92-1/Lead

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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