| Morphological changes of the arterial systems in the kidney under prolonged continuous flow left heart bypass. | |
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MedLine Citation:
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PMID: 12406155 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We investigated morphological changes of the arterial systems in the kidneys under prolonged continuous flow left heart bypass. Twelve goats were subjected to 2 weeks of pulsatile left heart bypass followed by 4 weeks of continuous flow left heart bypass (group CF). After autopsy, the kidneys underwent pathological evaluation. Six normal healthy goats were used as controls. The media of the afferent arterioles of group CF were frequently thickened by an increase in the number of the mature smooth muscle cells (SMCs). The juxtaglomerular areas (JGA) were expanded because of an increase in the number and size of SMCs and/or SMC-like cells. Furthermore, the percentage of anti-proliferating cell nuclear antigen antibody-positive cells in the JGA of group CF (9.9 +/- 1.9%) was significantly higher (p = 0.025) than that of the control group (4.6 +/- 3.4%), indicating active proliferation in group CF. We concluded that prolonged continuous flow left heart bypass causes proliferation of SMCs and/or SMC-like cells in the afferent arterioles and their perivascular tissue. |
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Authors:
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Hiroyuki Ohnishi; Tsuyoshi Itoh; Tomohiro Nishinaka; Eisuke Tatsumi; Toshihide Fukuda; Mitsuo Oshikawa; Kyoko Shioya; Tomonori Tsukiya; Yoshiaki Takewa; Akihiko Homma; Kunihiro Uesho; Koichi Sato; Hisateru Takano; Yoshiyuki Taenaka |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Artificial organs Volume: 26 ISSN: 0160-564X ISO Abbreviation: Artif Organs Publication Date: 2002 Nov |
Date Detail:
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Created Date: 2002-10-30 Completed Date: 2003-03-07 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7802778 Medline TA: Artif Organs Country: United States |
Other Details:
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Languages: eng Pagination: 974-9 Citation Subset: IM |
Affiliation:
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Department of Artificial Organs, National Cardiovascular Research Institute, Osaka, Japan. hohnishi@ri.ncvc.go.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cardiovascular Diseases / physiopathology*, therapy* Disease Models, Animal Goats Heart Bypass, Left* Hemodynamics / physiology Juxtaglomerular Apparatus / pathology, physiopathology Pulsatile Flow / physiology Renal Artery / pathology*, physiopathology Renal Circulation / physiology Time Factors Tunica Media / pathology, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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