Document Detail

Morphological changes of the arterial systems in the kidney under prolonged continuous flow left heart bypass.
MedLine Citation:
PMID:  12406155     Owner:  NLM     Status:  MEDLINE    
We investigated morphological changes of the arterial systems in the kidneys under prolonged continuous flow left heart bypass. Twelve goats were subjected to 2 weeks of pulsatile left heart bypass followed by 4 weeks of continuous flow left heart bypass (group CF). After autopsy, the kidneys underwent pathological evaluation. Six normal healthy goats were used as controls. The media of the afferent arterioles of group CF were frequently thickened by an increase in the number of the mature smooth muscle cells (SMCs). The juxtaglomerular areas (JGA) were expanded because of an increase in the number and size of SMCs and/or SMC-like cells. Furthermore, the percentage of anti-proliferating cell nuclear antigen antibody-positive cells in the JGA of group CF (9.9 +/- 1.9%) was significantly higher (p = 0.025) than that of the control group (4.6 +/- 3.4%), indicating active proliferation in group CF. We concluded that prolonged continuous flow left heart bypass causes proliferation of SMCs and/or SMC-like cells in the afferent arterioles and their perivascular tissue.
Hiroyuki Ohnishi; Tsuyoshi Itoh; Tomohiro Nishinaka; Eisuke Tatsumi; Toshihide Fukuda; Mitsuo Oshikawa; Kyoko Shioya; Tomonori Tsukiya; Yoshiaki Takewa; Akihiko Homma; Kunihiro Uesho; Koichi Sato; Hisateru Takano; Yoshiyuki Taenaka
Related Documents :
7618705 - Effect of esmolol given during cardiopulmonary bypass on fractional area of contraction...
19673945 - The novel selective toll-like receptor 4 signal transduction inhibitor tak-242 prevents...
17142825 - Haemodynamic effects of oxytocin given as i.v. bolus or infusion on women undergoing ca...
24881705 - The influence of intra-abdominal hypertension on the central nervous system: current in...
21840525 - Arterial stiffness and 24h ambulatory blood pressure monitoring in young healthy volunt...
10455475 - Hypertriglyceridaemia in mild hypertension: impact on cardiovascular and hormonal react...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Artificial organs     Volume:  26     ISSN:  0160-564X     ISO Abbreviation:  Artif Organs     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-10-30     Completed Date:  2003-03-07     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7802778     Medline TA:  Artif Organs     Country:  United States    
Other Details:
Languages:  eng     Pagination:  974-9     Citation Subset:  IM    
Department of Artificial Organs, National Cardiovascular Research Institute, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiovascular Diseases / physiopathology*,  therapy*
Disease Models, Animal
Heart Bypass, Left*
Hemodynamics / physiology
Juxtaglomerular Apparatus / pathology,  physiopathology
Pulsatile Flow / physiology
Renal Artery / pathology*,  physiopathology
Renal Circulation / physiology
Time Factors
Tunica Media / pathology,  physiopathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The application of quantitative oil streaking to the HeartQuest left ventricular assist device.
Next Document:  Nonlinear controller for ventricular assist devices.