Document Detail

Morphological and biochemical changes of neurofilaments in aged rat sciatic nerve axons.
MedLine Citation:
PMID:  14720223     Owner:  NLM     Status:  MEDLINE    
We have made a detailed comparison of neurofilaments (NFs) in the axons of the sciatic nerves between young and aged rats. In young rats, NF density was similar between proximal and distal sciatic nerve, but it became higher in the proximal region of sciatic nerve of aged rats. In accordance with this morphological change, NF protein content decreased dramatically in the middle region of the sciatic nerves of aged rats. The ratio of NF-M to NF-H in aged rats was lower than that in young rats at the proximal region of sciatic nerves and further decreased in the distal region of sciatic nerve. We analyzed transcription and axonal transport of NF proteins in motor neurons in spinal cord which are the major constituents of sciatic nerve axons. Of the transcripts of the NF subunits, NF-M mRNA was particularly reduced in aged rats. Examination of slow axonal transport revealed that the transport rate for NF-M was slightly faster than that for NF-H in young rats, but slightly slower in aged rats. A decrease in both the synthesis and transport rate of NF-M with aging may contribute to the relative reduction in NF-M in the aged rat sciatic nerve. Although the relationship between NF packing and reduced NF-M is not clear at present, these changes in NFs may be associated with age-dependent axonal degeneration diseases.
Atsuko Uchida; Tomoko Tashiro; Yoshiaki Komiya; Hiroshi Yorifuji; Takeo Kishimoto; Shin-ichi Hisanaga
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neurochemistry     Volume:  88     ISSN:  0022-3042     ISO Abbreviation:  J. Neurochem.     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-01-14     Completed Date:  2004-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2985190R     Medline TA:  J Neurochem     Country:  England    
Other Details:
Languages:  eng     Pagination:  735-45     Citation Subset:  IM    
Department of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachiohji, Japan.
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MeSH Terms
Aging / metabolism*,  pathology
Axonal Transport / physiology*
Axons / metabolism*,  pathology
Neurofilament Proteins / metabolism*
Sciatic Nerve / metabolism*,  pathology
Reg. No./Substance:
0/Neurofilament Proteins

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