| Morphological assessment of renal arteries after radiofrequency catheter-based sympathetic denervation in a porcine model. | |
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MedLine Citation:
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PMID: 22914572 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVES:: Catheter-based renal artery denervation has been successfully introduced as alternative treatment for patients suffering from drug-resistant essential hypertension. However, the local morphological changes within the vessel wall accompanying this technique remain elusive and we sought to characterize these by utilizing the simplicity radiofrequency catheter approach. METHODS:: Following treatment of seven pigs, renal arteries were assigned to either the acute (n = 6), subacute (10-day follow-up, n = 6) or control (untreated, n = 2) group. At follow-up blood analysis, final angiography and optical coherence tomography (OCT)-imaging of the treated arteries were performed and renal arteries and kidneys were processed for histopathology and immunohistochemistry. RESULTS:: Radiofrequency-derived energy application to the vessel wall induced transmural tissue coagulation and loss of endothelium resulting in local thrombus formation also detectable by OCT. At 10 days, the luminal surface was almost completely re-endothelialized. Mural wall damage was replaced by fibrotic tissue and the adventitial layer showed strong inflammatory infiltration including vasculogenesis. Remnant autonomic nerve fascicles within the lesion segments of the subacute group displayed enhanced vacuolic degeneration and an impaired neurofilament protein immunostaining pattern. Examination of the kidneys revealed no abnormalities and blood parameters remained within the physiological range. CONCLUSION:: Catheter-based application of radiofrequency energy resulted in circumscribed transmural injury within the arterial wall affecting autonomic nerve fascicles delayed to treatment. Acute loss of endothelialization resulted in thrombus formation leaving kidney perfusion apparently unimpaired. |
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Authors:
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Kristin Steigerwald; Anna Titova; Caroline Malle; Elisabeth Kennerknecht; Clemens Jilek; Jörg Hausleiter; Jörg M Nährig; Karl-Ludwig Laugwitz; Michael Joner |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-21 |
Journal Detail:
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Title: Journal of hypertension Volume: - ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aDeutsches Herzzentrum München und I. Med. Klinik der Technischen Universität München bInstitut für Allgemeine Pathologie und Pathologische Anatomie, Klinikum rechts der Isar, Technische Universität München, Munich, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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