| Morphological aspects of inhibition of transformation of rat kidney cells infected with a temperature-sensitive mutant of the Rous sarcoma virus by rat fibroblast interferon. | |
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MedLine Citation:
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PMID: 2168311 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal rat kidney cells (NRK) infected with a temperature-sensitive (ts) mutant of Rous Sarcoma virus (RSV) at the permissive temperature (33 degrees C) exhibit the morphological and growth characteristics of the transformed state. By the use of this system, it has been shown that the addition of rat fibroblast interferon to infected cells grown at a nonpermissive temperature (38 degrees C) prevents re-transformation when they are introduced to the permissive temperature. Merely treating cells at the permissive temperature with rat fibroblast interferon causes them to change from the transformed phenotype to a normal phenotype. These effects require the continuous presence of interferon and are quite species specific as observed with the ineffectiveness of mouse fibroblast interferon. Therefore, the results suggest that interferon might restore the growth control of transformed cells which could in part accounts for its anti-tumor effect. |
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Authors:
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Y C Chen; W W Wu; K A Borchardt |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology Volume: 23 ISSN: 0253-2662 ISO Abbreviation: Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-10-10 Completed Date: 1990-10-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008067 Medline TA: Zhonghua Min Guo Wei Sheng Wu Ji Mian Yi Xue Za Zhi Country: TAIWAN |
Other Details:
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Languages: eng Pagination: 101-5 Citation Subset: IM |
Affiliation:
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Center for Advanced Medical Technology, San Francisco State University, California 94132. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Avian Sarcoma Viruses / drug effects* Cell Transformation, Viral / drug effects* Interferon Type I / pharmacology* Kidney / pathology Rats |
| Chemical | |
Reg. No./Substance:
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0/Interferon Type I |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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