Document Detail

Morphological adaptation of the cardiovascular system in fetal rats during late gestation.
MedLine Citation:
PMID:  10598687     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate morphological changes of the cardiovascular system in fetal rats during late gestation. We used the rapid whole-body freezing technique for rats of day 17 through 21 of gestation. The right and left ventricular volumes increased markedly and significantly during this period by about 11- and 24-fold, respectively. Although the right ventricular volume was 108% larger with statistical significance than the left ventricular volume on day 17, they were almost equal after day 19. The length of the primum septum of the atrium significantly increased by 92% within 4 days, but the opening distance of foramen ovale significantly decreased by 14%. The ratio of the inner diameter (the sum of right and left pulmonary arteries to ductus arteriosus) significantly increased from 0.72+/-0.03 on day 17 to 1.17+/-0.07 on day 21. There was also a significant increase in the ratio of the inner diameters of the ascending to descending aorta. These observations suggest that the reduction of the opening distance of foramen ovale reflect the growth of pulmonary arteries.
M Toyono; T Ito; K Harada; M Tamura; G Takada
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  188     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  2000-01-12     Completed Date:  2000-01-12     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  299-309     Citation Subset:  IM    
Department of Pediatrics, Akita University School of Medicine, Japan.
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MeSH Terms
Adaptation, Physiological / physiology*
Aorta / anatomy & histology,  embryology
Cardiovascular Physiological Phenomena*
Ductus Arteriosus / anatomy & histology,  embryology
Fetus / physiology*
Gestational Age*
Heart / anatomy & histology,  embryology
Heart Septum / embryology
Heart Ventricles / anatomy & histology,  embryology
Pregnancy, Animal / physiology*
Pulmonary Artery / anatomy & histology,  embryology
Rats, Wistar
Tissue Embedding
Venae Cavae / anatomy & histology,  embryology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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