| Morphological abnormalities in the brains of estrogen receptor beta knockout mice. | |
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MedLine Citation:
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PMID: 11226319 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Estrogen receptor beta (ERbeta) is expressed at high levels in both neurons and glial cells of the central nervous system. The development of ERbeta knockout (BERKO) mice has provided a model to study the function of this nuclear receptor in the brain. We have found that the brains of BERKO mice show several morphological abnormalities. There is a regional neuronal hypocellularity in the brain, with a severe neuronal deficit in the somatosensory cortex, especially layers II, III, IV, and V, and a remarkable proliferation of astroglial cells in the limbic system but not in the cortex. These abnormalities are evident as early as 2 mo of age in BERKO mice. As BERKO mice age, the neuronal deficit becomes more pronounced, and, by 2 yr of age, there is degeneration of neuronal cell bodies throughout the brain. This is particularly evident in the substantia nigra. We conclude that ERbeta is necessary for neuronal survival and speculate that this gene could have an important influence on the development of degenerative diseases of the central nervous system, such as Alzheimer's disease and Parkinson's disease, as well as those resulting from trauma and stroke in the brain. |
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Authors:
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L Wang; S Andersson; M Warner; J A Gustafsson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2001-02-20 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 98 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2001 Feb |
Date Detail:
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Created Date: 2001-03-06 Completed Date: 2001-09-13 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 2792-6 Citation Subset: IM |
Affiliation:
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Department of Medical Nutrition, Karolinska Institute, NOVUM, S-141 86 Huddinge, Sweden. ling.wang@mednut.ki.se |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / abnormalities*, metabolism Estrogen Receptor beta Glial Fibrillary Acidic Protein / metabolism Immunohistochemistry Male Mice Mice, Inbred C57BL Mice, Knockout Receptors, Estrogen / genetics, metabolism, physiology* Species Specificity |
| Chemical | |
Reg. No./Substance:
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0/Estrogen Receptor beta; 0/Glial Fibrillary Acidic Protein; 0/Receptors, Estrogen |
| Comments/Corrections | |
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