Document Detail


Morphological modification of the cornea after standard and transepithelial corneal cross-linking as imaged by anterior segment optical coherence tomography and laser scanning in vivo confocal microscopy.
MedLine Citation:
PMID:  23538618     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
PURPOSE: In vivo analysis of corneal modifications after traditional and transepithelial corneal cross-linking (CXL).
METHODS: Forty eyes of 35 patients underwent traditional or transepithelial CXL; there was randomization of 20 eyes to each group. By means of in vivo confocal microscopy and anterior segment ocular coherence tomography, we evaluated corneal alterations at 1 week, 1 month, and 3, 6, and 12 months after the treatment.
RESULTS: During follow-up, in vivo confocal microscopy showed a significant decrease in anterior keratocyte density (P = 0.001) and more evident stromal edema and keratocyte activation (P = 0.001) in the traditional group, whereas in the transepithelial group, no significant changes were observed (P > 0.05). Anterior segment ocular coherence tomography indicated the presence of hyperreflective stromal line significantly deeper and more persistent in the traditional group (P < 0.001).
CONCLUSIONS: The preliminary results suggest that traditional CXL induced marked corneal modifications, which were poorly evident in the transepithelial group.
Authors:
Leonardo Mastropasqua; Mario Nubile; Manuela Lanzini; Roberta Calienno; Rodolfo Mastropasqua; Luca Agnifili; Lisa Toto
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Publication Detail:
Type:  Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Cornea     Volume:  32     ISSN:  1536-4798     ISO Abbreviation:  Cornea     Publication Date:  2013 Jun 
Date Detail:
Created Date:  2013-05-10     Completed Date:  2013-09-19     Revised Date:  2013-12-09    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  855-61     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Cell Count
Collagen / metabolism
Corneal Edema / diagnosis*
Corneal Keratocytes / pathology*
Corneal Pachymetry
Corneal Stroma / metabolism
Corneal Topography
Cross-Linking Reagents / therapeutic use*
Female
Humans
Keratoconus / drug therapy*,  metabolism
Male
Microscopy, Confocal
Photochemotherapy*
Photosensitizing Agents / therapeutic use
Prospective Studies
Riboflavin / therapeutic use
Tomography, Optical Coherence
Ultraviolet Rays
Young Adult
Chemical
Reg. No./Substance:
0/Cross-Linking Reagents; 0/Photosensitizing Agents; 9007-34-5/Collagen; TLM2976OFR/Riboflavin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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