Document Detail

Morphological and immunohistochemical characterization of spontaneous mammary gland tumors in the guinea pig (Cavia porcellus).
MedLine Citation:
PMID:  20106793     Owner:  NLM     Status:  MEDLINE    
Ten spontaneous mammary gland tumors affecting guinea pigs (GP) were analyzed histologically and immunohistochemically. Histologically, 3 were benign (2 simple adenomas and 1 benign mixed tumor) and 7 were malignant (1 simple solid carcinoma and 6 simple tubulopapillary carcinomas). Immunohistochemical data revealed the glandular immunoprofile of all the tumors and suggested their ductal origin on the basis of cytokeratin 20 expression. Interestingly, cytokeratin 7 was detected in basal/myoepithelial cells. Further, all tumors were positive for type alpha estrogen and progesterone receptors, suggesting a role for steroid hormones in the development of these neoplasias in GP. This article describes the morphological and immunohistochemical features of the normal mammary gland and spontaneous mammary gland tumors in GP.
A Su?rez-Bonnet; J Mart?n de Las Mulas; M Y Mill?n; P Herr?ez; F Rodr?guez; A Espinosa de los Monteros
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Publication Detail:
Type:  Journal Article     Date:  2009-12-31
Journal Detail:
Title:  Veterinary pathology     Volume:  47     ISSN:  1544-2217     ISO Abbreviation:  Vet. Pathol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-31     Completed Date:  2010-07-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0312020     Medline TA:  Vet Pathol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  298-305     Citation Subset:  IM    
Unit of Histology and Animal Pathology, Institute for Animal Health, Veterinary School, University of Las Palmas de Gran Canaria, Arucas (Gran Canaria), Spain.
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MeSH Terms
Adenocarcinoma / metabolism,  pathology,  veterinary*
Estrogen Receptor alpha / metabolism
Guinea Pigs*
Immunohistochemistry / veterinary
Mammary Neoplasms, Animal / metabolism,  pathology*
Receptors, Progesterone / metabolism
Retrospective Studies
Rodent Diseases / metabolism,  pathology*
Reg. No./Substance:
0/Estrogen Receptor alpha; 0/Receptors, Progesterone

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