Document Detail

Morphological and functional alterations in the aorta of the chronically hypoxic fetal rat.
MedLine Citation:
PMID:  21985843     Owner:  NLM     Status:  MEDLINE    
In human pregnancy, reduced placental perfusion has been associated with fetal aortic thickening. However, the relative contributions of fetal undernutrition versus fetal underoxygenation to triggering alterations in fetal cardiovascular development remain uncertain. Here, we isolate the effects of chronic fetal hypoxia on fetal cardiovascular development in a specific rodent model of chronic fetal hypoxia independent of changes in nutrition during pregnancy. Pregnant rats were housed under normoxic (21% O(2)) or hypoxic (13% O(2)) conditions from day 6 to day 20 of gestation. At day 20, pups and placentas were weighed. Fetal thoraces were fixed for quantitative histological analysis of the aorta. In a separate group, fetal aortic reactivity was assessed via in vitro wire myography. The experiments controlled for sex and within-litter variation. Placental weight was increased and fetal weight maintained in hypoxic pregnancy. Hypoxic pregnancy led to a 176% increment in wall thickness and a 170% increment in the wall-to-lumen area ratio of the fetal aorta. Fetal aortic vascular reactivity was markedly impaired, showing reduced constrictor and relaxant responsiveness in hypoxic pregnancy. Chronic developmental hypoxia independent of changes in nutrition has profound effects on the morphology and function of the fetal aorta in a mammalian species.
Emilio A Herrera; Emily J Camm; Christine M Cross; Joanne L Mullender; F B Peter Wooding; Dino A Giussani
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-10-06
Journal Detail:
Title:  Journal of vascular research     Volume:  49     ISSN:  1423-0135     ISO Abbreviation:  J. Vasc. Res.     Publication Date:  2012  
Date Detail:
Created Date:  2011-12-19     Completed Date:  2012-02-07     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  9206092     Medline TA:  J Vasc Res     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  50-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
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MeSH Terms
Aorta / pathology*,  physiopathology*
Chronic Disease
Fetal Hypoxia / pathology*,  physiopathology*
Fetal Weight
Nitric Oxide / physiology
Organ Size
Placenta / pathology
Rats, Wistar
Grant Support
PG/10/99/28656//British Heart Foundation; //Biotechnology and Biological Sciences Research Council; //British Heart Foundation
Reg. No./Substance:
31C4KY9ESH/Nitric Oxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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