| Morphologic observations in biologic conduits between aorta and coronary artery. | |
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MedLine Citation:
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PMID: 332366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This report describes morphologic observations in autogenous saphenous veins, autogenous internal mammary arteries, radial arteries and arterial heterografts used as aortocoronary bypass conduits. The normal or expected changes and the abnormal or unexpected changes observed in each type of bypass conduit is discussed. The three major changes seen in saphenous vein grafts in the aortocoronary position are: (1) medial fibrous replacement; (2) adventitial fibrous proliferation; and (3) intimal fibrous proliferation. Medial fibrous replacement is the result of vein wall ischemia and necrosis and ultimately replacement of smooth muscle cells; adventitial fibrosis is the result of organization of fibrin and red cell clot and repair of ischemic damage. The cause of intimal fibrous proliferation is unclear but appears to be the result of chronic repair of injured intima and endothelium. That the severity of the changes varies along the length of one graft or among grafts in the same patient suggests that other factors contribute to the development of the changes observed. Although some structural changes have been observed, internal mammary arteries are relatively resistant to the changes seen in saphenous veins. Radial arterial grafts have shown severe structural changes with time, to a degree greater than that seen in the saphenous vein grafts. Heterograft conduits so far have been unsuccessful in the aortocoronary position in humans. The severe changes seen in radial artery and heterograft conduits indicate that they are inadequate for use as substitutes for saphenous vein and mammary artery as bypass conduits from aorta to coronary artery. |
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Authors:
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T L Spray; W C Roberts |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Cardiovascular clinics Volume: 8 ISSN: 0069-0384 ISO Abbreviation: Cardiovasc Clin Publication Date: 1977 |
Date Detail:
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Created Date: 1977-11-25 Completed Date: 1977-11-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0213744 Medline TA: Cardiovasc Clin Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 11-40 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Arm / innervation Arteries / pathology, transplantation Carotid Arteries / transplantation Coronary Artery Bypass* Coronary Vessels / pathology Dogs Female Humans Internal Mammary-Coronary Artery Anastomosis Male Mammary Arteries / anatomy & histology, pathology* Middle Aged Saphenous Vein / anatomy & histology, pathology*, transplantation Sheep Thoracic Arteries / pathology* Transplantation, Autologous Transplantation, Heterologous |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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