| Morphologic findings of the ischemic myocardium. | |
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MedLine Citation:
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PMID: 16533187 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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This study assesses the relation between qualitative and quantitative findings of myocytes and interstitial connective tissue in the ischemic heart disease. Qualitative and quantitative changes of myocytes and interstitial connective tissue were studied on the serial cross myocardial sections from 20 autopsied hearts with ischemic lesions, stained by immunohistochemistry using a monoclonal antibody (von Willebrand factor) and with hematoxylin-eosin method. Myocardial sections included proximal and distal part of occlusion and area of occlusion of coronary vessels. The volume densities (V V) of the cardiac myocytes and interstitial fibrosis in the group with coronary occlusion were examined stereologically and compared with control group. The findings showed a significant reduction in the volume density of myocytes and an increase in the volume density of interstitial fibrosis in patients with coronary occlusion compared with control group. Significant reduction in the volume density of myocytes and an increase in volume density of interstitial fibrosis were greater in the distal part of occlusion and area of occlusion, than in the proximal part of the occlusion. Our stereological results give useful quantitative information's of changes in myocardium parts during coronary occlusion as well as in normal conditions, and represent objective proof of significant changes in ischemic myocardium described by qualitative analyses. |
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Authors:
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Aida Hasanović; Zakira Mornjaković; Branko Pikula; Faruk Dilberović |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences Volume: 6 ISSN: 1512-8601 ISO Abbreviation: Bosn J Basic Med Sci Publication Date: 2006 Feb |
Date Detail:
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Created Date: 2006-03-14 Completed Date: 2006-05-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101200947 Medline TA: Bosn J Basic Med Sci Country: Bosnia and Hercegovina |
Other Details:
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Languages: eng Pagination: 82-5 Citation Subset: IM |
Affiliation:
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Department of Anatomy, Faculty of Medicine, University of Sarajevo, Cekalusa 90, 71000 Sarajevo, Bosnia and Herzegovina. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Cell Count Connective Tissue / pathology Coronary Disease / pathology Fibrosis Humans Myocardial Ischemia / pathology* Myocytes, Cardiac / pathology |
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