Document Detail


Morphologic features of the rheumatic mitral regurgitant valve by three-dimensional echocardiography.
MedLine Citation:
PMID:  11685179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Rheumatic fever remains a significant worldwide cause of mitral regurgitation (MR). We describe morphologic features of the rheumatic MR valve by quantitative 3-dimensional (3D) echocardiography. METHODS: Eight healthy subjects and 16 patients with less than moderate (n = 7) or more than or equal to moderate (n = 9) rheumatic MR underwent 3D echocardiography by use of freehand transthoracic scanning. Left ventricular (LV) borders, mitral chordae, papillary muscles and annuli were traced at end-diastole (ED) and end-systole (ES) with LV surfaces and mitral annulus reconstructed in 3D. Regional LV function was quantified by myocardial thickening. Regional LV shape was assessed by alignment of diseased ED endocardial surfaces to a reference normal surface. RESULTS: In the diseased group, LVs were more spheric and had regional shape abnormality in the area of anterior papillary muscle attachment. LV volumes, ejection fraction, and regional function in the areas of papillary attachment were not different. Mitral annular length and area were increased and correlated with LVED volume but were no different in height, sphericity, or beat-to-beat deformity. Chordal and papillary muscle lengths were not reduced. The interchordal angle (between the anterior and posterior chordae) was more acute in MR. CONCLUSION: Alterations in LV geometry and mitral apparatus morphologic features contribute to rheumatic regurgitant disease. Consequent changes include malalignment of the papillary muscles and a narrowed interchordal angle that is opposite to the widening seen in MR from dilated cardiomyopathy. We hypothesize that leaflet involvement with retraction causes increased tension on the chordae, a reduction in the interchordal angle, and a consequent coaptation defect.
Authors:
S Wong; R French; E Bolson; J McDonald; M Legget; F Sheehan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American heart journal     Volume:  142     ISSN:  1097-6744     ISO Abbreviation:  Am. Heart J.     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-30     Completed Date:  2002-01-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370465     Medline TA:  Am Heart J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  897-907     Citation Subset:  AIM; IM    
Affiliation:
Green Lane Hospital, Auckland, New Zealand.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Chordae Tendineae / anatomy & histology,  pathology,  physiopathology
Echocardiography, Three-Dimensional / statistics & numerical data*
Female
Heart Ventricles / anatomy & histology,  pathology,  physiopathology
Humans
Image Processing, Computer-Assisted
Male
Middle Aged
Mitral Valve / anatomy & histology,  pathology,  physiopathology*
Mitral Valve Insufficiency / diagnosis*,  pathology
Myocardial Contraction / physiology
Papillary Muscles / anatomy & histology,  pathology,  physiopathology
Rheumatic Heart Disease / diagnosis*,  pathology,  physiopathology
Severity of Illness Index
Ventricular Function, Left / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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