Document Detail

Morphologic evaluation of meibomian glands in chronic graft-versus-host disease using in vivo laser confocal microscopy.
MedLine Citation:
PMID:  22025888     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To evaluate the morphological changes of the meibomian glands (MGs) using in vivo laser confocal microscopy (CM) in dry eye (DE) patients with chronic graft-versus-host disease (cGVHD).
METHODS: Seventeen eyes from 9 patients with a diagnosis of DE associated with cGVHD (DE/cGVHD group; 6 males, 3 females; median 50.5 years) and 16 eyes of 8 hematopoietic stem cell transplantation (HSCT) recipients without DE (non-DE/non-cGVHD group; 5 males, 3 females; median 47.0 years) were enrolled. CM was used to investigate the MG and MG acinar unit density (MGAUD), MG acinar longest diameter (MGALD), MG acinar shortest diameter (MGASD), and the fibrosis grade. Clinical findings of the lid margin were obtained. Tear dynamics, ocular surface vital staining, meibography, and MG expressibility were also examined. Data were compared between the 2 groups using the unpaired t and Mann-Whitney tests.
RESULTS: The mean MGAUD value was significantly lower in the DE/cGVHD group than in the non-DE/non-cGVHD group (p=0.01, 57.8±38.3 glands/mm(2), 88.8±26.6 glands/mm(2), respectively), and the mean MGALD and MGASD were significantly shorter in the DE/cGVHD group than in the non-DE/non-cGVHD group (p=0.0018, 37.3±24.4 μm and 60.4±11.8 μm, p=0.0106, 17.7±11.8 μm and 26.6±6.03 μm, respectively). The mean fibrosis grade was significantly higher in the DE/cGVHD group than the non-DE/non-cGVHD group (p<0.0001, 1.39±0.71 grade, 0.06±0.25 grade, respectively). Clinical findings in the lid margin, tear dynamics, and ocular surface findings were significantly worse in the DE/cGVHD group than in the non-DE/non-cGVHD group.
CONCLUSIONS: CM clearly depicted the morphological changes of the MG in the DE/cGVHD group, and revealed the severity of the meibomian gland dysfunction. Patients with severe DE after HSCT showed atrophic MG and excessive fibrosis.
Yumiko Ban; Yoko Ogawa; Osama M A Ibrahim; Yukako Tatematsu; Mizuka Kamoi; Miki Uchino; Saori Yaguchi; Murat Dogru; Kazuo Tsubota
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-29
Journal Detail:
Title:  Molecular vision     Volume:  17     ISSN:  1090-0535     ISO Abbreviation:  Mol. Vis.     Publication Date:  2011  
Date Detail:
Created Date:  2011-10-25     Completed Date:  2012-02-10     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9605351     Medline TA:  Mol Vis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2533-43     Citation Subset:  IM    
Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan.
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MeSH Terms
Case-Control Studies
Chronic Disease
Dry Eye Syndromes / etiology,  pathology*
Fibrosis / etiology,  pathology*
Graft vs Host Disease / etiology,  pathology*
Hematopoietic Stem Cell Transplantation / adverse effects*
Meibomian Glands / pathology*,  ultrastructure
Microscopy, Confocal / methods*
Middle Aged
Prospective Studies
Tears / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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