| Morphologic development of experimental cholesteatoma. | |
| | |
MedLine Citation:
|
PMID: 8435164 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Using light microscopy, we studied the morphologic events of cholesteatoma progression 8 months after ligation of the ear canal in 14 Mongolian gerbils. Although we observed a wide range of progression, four stages of morphologic development could be clearly distinguished among the 28 specimens: stage I, an orthokeratotic plug in the ear canal without tympanic membrane involvement; stage II, partial retraction of the tympanic membrane; stage III, the interface between cholesteatoma encapsulated within the tympanic membrane and mucosal membranes covering the promontorial wall of the middle-ear cavity was characterized by a buildup of granulation tissue with prominent macrophage infiltration; and stage IV, bone destruction. Chronic inflammation was observed in some but not all stage II to IV cases. Our results indicate that hyperkeratosis is a primary event in cholesteatoma development, that the development of the granulation tissue with activated macrophages may be responsible for the bone destruction, and that acute or chronic inflammation is not a prerequisite for the development of cholesteatoma or the bone resorptive process. |
| | |
Authors:
|
B Aberg; S Edström; D Bagger-Sjöbäck; L G Kindblom |
Related Documents
:
|
22969864 - Cryotherapy is associated with improved clinical outcomes of sorafenib for the treatmen... 23446204 - Fdg pet-ct aids in the preoperative assessment of patients with newly diagnosed thymic ... 1845874 - Extrarenal wilms' tumor: staging, treatment, and prognosis. 11426744 - Prognosis and survival after resection for bronchogenic carcinoma based on the 1997 tnm... 19574884 - Evaluation of venous invasion by elastica van gieson stain and tumor budding predicts l... 9303054 - Analysis of prognostic factors for patients with single brain metastasis treated with s... |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Archives of otolaryngology--head & neck surgery Volume: 119 ISSN: 0886-4470 ISO Abbreviation: Arch. Otolaryngol. Head Neck Surg. Publication Date: 1993 Mar |
Date Detail:
|
Created Date: 1993-03-25 Completed Date: 1993-03-25 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8603209 Medline TA: Arch Otolaryngol Head Neck Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 272-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Otorhinolaryngology, University of Göteborg, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cholesteatoma / pathology* Disease Models, Animal Ear Canal / pathology* Ear Diseases / pathology* Ear, Middle / pathology* Gerbillinae Temporal Bone / pathology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Clinical behavior of acoustic tumors. A flow cytometric analysis.
Next Document: External and middle ear status related to evoked otoacoustic emission in neonates.