Document Detail


Morphologic and cytochemical characteristics of acute promyelocytic leukemia.
MedLine Citation:
PMID:  2539013     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The existence of two distinct subtypes of acute promyelocytic leukemia was confirmed and characterized based on morphologic features of leukemic cells in a series of 63 patients studied by the Cancer and Leukemia Group B (CALGB). Seventeen patients (27%) had microgranular leukemic cells (M3V), and 46 patients (73%) had hypergranular leukemic cells (M3). These patient cohorts were studied for other laboratory and clinical features. Leukemic cells from M3V patients stained less frequently than leukemic cells from M3 patients for myeloperoxidase (median, 93% vs. 99%; P = .006), periodic acid-Schiff (median, 57% vs. 92%; P = .0001), ASD-chloroacetate esterase (median, 45% vs. 87%; P less than .0001), and alpha-naphthyl acetate esterase (0% vs. 37%; P = .0003). Patients with M3V had a higher platelet count (median, 50 vs. 30 x 10(9)/L; P = .01) and tended to have a higher leukocyte count (median, 7.4 vs. 2.2 x 10(9)/L; P = .06) than M3 patients. The patients with M3V morphology were more likely to be nonwhite (29% vs. 7%; P = .03), female (71% vs. 37%; P = .02), and to be infected at the time of presentation (71% vs. 35%; P = .02). No differences in the frequency of the t(15;17) karyotype or the immunophenotypic expression of the leukemic cells were noted in the two morphologic subtypes of acute promyelocytic leukemia. Fewer patients with M3V tended to enter complete remission (65% vs. 80%; P = .20), but no significant differences were found in the duration of complete remission (P = .81; 1 year rate, 50% vs. 85%), or probability of survival (P = .67; 1 year rate, 49% vs. 68%).
Authors:
F R Davey; R B Davis; J M MacCallum; D A Nelson; R J Mayer; E D Ball; J D Griffin; C A Schiffer; C D Bloomfield
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  30     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1989 Apr 
Date Detail:
Created Date:  1989-04-21     Completed Date:  1989-04-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-7     Citation Subset:  IM    
Affiliation:
Cancer and Leukemia Group B, Brookline, Massachusetts.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Granulocytes / pathology,  ultrastructure
Histocytochemistry
Humans
Leukemia, Promyelocytic, Acute / enzymology,  pathology*
Naphthol AS D Esterase / analysis
Peroxidase / analysis
Grant Support
ID/Acronym/Agency:
CA12011/CA/NCI NIH HHS; CA37027/CA/NCI NIH HHS; CA37055/CA/NCI NIH HHS
Chemical
Reg. No./Substance:
EC 1.11.1.7/Peroxidase; EC 3.1.-/Naphthol AS D Esterase
Comments/Corrections
Comment In:
Am J Hematol. 1990 Mar;33(3):223   [PMID:  2301383 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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