Document Detail

Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of retinal light damage.
MedLine Citation:
PMID:  1428709     Owner:  NLM     Status:  MEDLINE    
The histologic manifestations of rhodopsin-mediated versus short-wavelength classes of retinal phototoxicity were compared after spectral exposures of the albino rat retina. Animals were exposed to wave-bands of light centered at the peak of rhodopsin absorbance (green, 500 nm) or in the ultraviolet A (UVA; 360 nm). Intensity-damage curves generated for each wave-band indicated that UVA light was 50-80 times more effective than green light at causing photoreceptor cell losses. Examination of early ultrastructural changes in rod inner segments, outer segments, and retinal pigment epithelium revealed a remarkable degree of similarity between UVA and green light-induced damage. Furthermore, the two classes of damage were indistinguishable in terms of post-exposure recovery from threshold damage and regional distribution of photoreceptor cell loss along the vertical meridian. The finding of essentially identical histologic manifestations for the two classes of damage raises the possibility that they share a common biochemical etiology or pathway of cell destruction.
L M Rapp; S C Smith
Related Documents :
21262119 - Dark-phase light contamination disrupts circadian rhythms in plasma measures of endocri...
24104319 - Simulating the spatial luminance distribution of planar light sources by sampling of ra...
22828629 - Plasmonic black gold by adiabatic nanofocusing and absorption of light in ultra-sharp c...
15161869 - Photoreceptor degeneration and loss of retinal function in the c57bl/6-c2j mouse.
1428709 - Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of reti...
10375439 - Influence of uva light stress on photoreceptor cell metabolism: decreased rates of rhod...
11572429 - Variation of consumer contact with household products: a preliminary investigation.
17576349 - Dynamic holography in bacteriorhodopsin/gelatin films: effects of light-dark adaptation...
20649189 - Differences in distortion product otoacoustic emission phase recorded from human neonat...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  33     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-17     Completed Date:  1992-12-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3367-77     Citation Subset:  IM    
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Differential Threshold
Dose-Response Relationship, Radiation
Light / adverse effects*
Photoreceptor Cells / radiation effects,  ultrastructure
Pigment Epithelium of Eye / radiation effects,  ultrastructure
Radiation Injuries, Experimental / etiology*,  pathology
Rats, Sprague-Dawley
Retinal Diseases / etiology*,  pathology
Rhodopsin / physiology*
Ultraviolet Rays / adverse effects
Grant Support
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Comparison of external and internal approaches for transplantation of autologous retinal pigment epi...
Next Document:  Dissociation between prostaglandin levels and blood flow to the retina and choroid in the newborn pi...