Document Detail


Morphologic comparisons between rhodopsin-mediated and short-wavelength classes of retinal light damage.
MedLine Citation:
PMID:  1428709     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The histologic manifestations of rhodopsin-mediated versus short-wavelength classes of retinal phototoxicity were compared after spectral exposures of the albino rat retina. Animals were exposed to wave-bands of light centered at the peak of rhodopsin absorbance (green, 500 nm) or in the ultraviolet A (UVA; 360 nm). Intensity-damage curves generated for each wave-band indicated that UVA light was 50-80 times more effective than green light at causing photoreceptor cell losses. Examination of early ultrastructural changes in rod inner segments, outer segments, and retinal pigment epithelium revealed a remarkable degree of similarity between UVA and green light-induced damage. Furthermore, the two classes of damage were indistinguishable in terms of post-exposure recovery from threshold damage and regional distribution of photoreceptor cell loss along the vertical meridian. The finding of essentially identical histologic manifestations for the two classes of damage raises the possibility that they share a common biochemical etiology or pathway of cell destruction.
Authors:
L M Rapp; S C Smith
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Investigative ophthalmology & visual science     Volume:  33     ISSN:  0146-0404     ISO Abbreviation:  Invest. Ophthalmol. Vis. Sci.     Publication Date:  1992 Nov 
Date Detail:
Created Date:  1992-12-17     Completed Date:  1992-12-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7703701     Medline TA:  Invest Ophthalmol Vis Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3367-77     Citation Subset:  IM    
Affiliation:
Cullen Eye Institute, Baylor College of Medicine, Houston, Texas 77030.
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MeSH Terms
Descriptor/Qualifier:
Animals
Differential Threshold
Dose-Response Relationship, Radiation
Female
Light / adverse effects*
Photoreceptor Cells / radiation effects,  ultrastructure
Pigment Epithelium of Eye / radiation effects,  ultrastructure
Radiation Injuries, Experimental / etiology*,  pathology
Rats
Rats, Sprague-Dawley
Retinal Diseases / etiology*,  pathology
Rhodopsin / physiology*
Ultraviolet Rays / adverse effects
Grant Support
ID/Acronym/Agency:
EY-02520/EY/NEI NIH HHS; EY-04554/EY/NEI NIH HHS
Chemical
Reg. No./Substance:
9009-81-8/Rhodopsin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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