Document Detail

Morphologic changes in the thyroid after irradiation for Hodgkin's and non-Hodgkin's lymphoma.
MedLine Citation:
PMID:  2743276     Owner:  NLM     Status:  MEDLINE    
Four cases of thyroidectomy for suspected thyroid carcinoma after previous irradiation for Hodgkin's or non-Hodgkin's lymphoma are reviewed. The patients ranged in age from 18 to 33 years at the time of thyroid surgery with an average latency period of 12 years (range, 8-20 years) from radiation therapy to thyroidectomy. All patients had a clinically palpable thyroid nodule, and pathologically showed a pattern of multiple adenomatous nodules with cytologic atypia. The microscopic changes were sufficiently striking to cause the primary pathologist to request consultation to rule out thyroid carcinoma in each case. Fine-needle aspiration was performed in one case and suggested a thyroid neoplasm. The pathologic findings are reviewed and distinction of this lesion from thyroid carcinoma is discussed.
R F Carr; V A LiVolsi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cancer     Volume:  64     ISSN:  0008-543X     ISO Abbreviation:  Cancer     Publication Date:  1989 Aug 
Date Detail:
Created Date:  1989-08-25     Completed Date:  1989-08-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0374236     Medline TA:  Cancer     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  825-9     Citation Subset:  AIM; IM    
Department of Pathology, Hospital of the University of Pennsylvania, Philadelphia 19104.
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MeSH Terms
Diagnosis, Differential
Hodgkin Disease / radiotherapy*
Lymphoma, Non-Hodgkin / radiotherapy*
Neoplasms, Radiation-Induced / pathology,  surgery*
Radiotherapy / adverse effects
Radiotherapy Dosage
Thyroid Gland / pathology,  radiation effects*
Thyroid Neoplasms / etiology,  pathology,  surgery*

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