Document Detail

Morphologic changes in the hypertensive placenta.
MedLine Citation:
PMID:  6754249     Owner:  NLM     Status:  MEDLINE    
Pregnancy complicated by hypertension is commonly associated with placental insufficiency, thereby resulting in fetal growth retardation. Furthermore, reduced utero-placental blood flow has been recognized in cases of severe preeclampsia with hypertension. Thus, it must be assumed that histological as well as ultrastructural findings in hypertensive placentas are due to the occlusion or narrowing of the uteroplacental vasculature as well as placental ischemia. Microscopically, these placental changes include infarcts, increased syncytial knots, hypovascularity of the villi, cytotrophoblastic proliferation, thickening of the trophoblastic basement membrane, obliterative enlarged endothelial cells in the fetal capillaries and atherosis of the spiral arteries in the placental bed. In addition, ultrastructural features are characterized by a decreased number of syncytial microvilli, proliferation of cytotrophoblastic cells, focal syncytial necrosis, thickening of trophoblastic basement membrane and narrowing of the fetal capillaries, as a number of studies have demonstrated. These placental abnormalities can be seen not only in human toxemia, but also in animals with experimentally induced toxemia or with spontaneous toxemia.
H Soma; K Yoshida; T Mukaida; Y Tabuchi
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Contributions to gynecology and obstetrics     Volume:  9     ISSN:  0304-4246     ISO Abbreviation:  Contrib Gynecol Obstet     Publication Date:  1982  
Date Detail:
Created Date:  1983-01-19     Completed Date:  1983-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7702984     Medline TA:  Contrib Gynecol Obstet     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  58-75     Citation Subset:  IM    
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MeSH Terms
Arteries / pathology
Basement Membrane / pathology
Capillaries / pathology
Chorionic Villi / pathology
Fetal Growth Retardation / etiology
Hypertension / complications,  pathology*
Infarction / etiology,  pathology
Organ Size
Placenta / blood supply,  pathology*,  ultrastructure
Pre-Eclampsia / immunology,  pathology*
Pregnancy Complications, Cardiovascular / pathology*
Trophoblasts / pathology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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