| Morphogens in vertebrate development: how do they work? | |
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MedLine Citation:
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PMID: 7748169 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The idea that concentration gradients of crucial substances might control the pattern of development, even in the embryos of complex organisms, has been around for a long time, but mostly in obscure forms. Twenty five years ago clear, experimentally testable ideas about how such gradients might work were enunciated, and more recently the morphogen gradient principle was shown to underlie the beginnings of patterning in Drosophila. Is it also central to vertebrate development? Four recent papers raise experimentation to a new level, while showing how difficult it might be to pin down the precise form of the mechanism. |
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Authors:
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J Cooke |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: BioEssays : news and reviews in molecular, cellular and developmental biology Volume: 17 ISSN: 0265-9247 ISO Abbreviation: Bioessays Publication Date: 1995 Feb |
Date Detail:
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Created Date: 1995-06-13 Completed Date: 1995-06-13 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 8510851 Medline TA: Bioessays Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 93-6 Citation Subset: IM |
Affiliation:
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National Institute for Medical Research, Mill Hill, London, UK. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Drosophila / embryology Morphogenesis* Signal Transduction Vertebrates / embryology* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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