Document Detail

Morphogenic potentials of D2, D3, and D4 dopamine receptors revealed in transfected neuronal cell lines.
MedLine Citation:
PMID:  7904756     Owner:  NLM     Status:  MEDLINE    
Molecular cloning studies have defined a family of dopamine D2-like receptors (D2, D3, and D4), which are the products of separate genes. Our previous work has shown that stimulation of dopamine D2-like receptors in cultures of fetal cortical neurons increases the extension and branching of neurites. To determine which D2-like receptors possess morphogenic potentials, a clonal mesencephalic cell line (MN9D) was transfected with D2, D3, or D4 receptor subtypes and treated with quinpirole, an agonist of D2-like receptors, and changes in morphological characteristics were quantitated. Stimulation of D2 receptors increased the number and branching of neurites with little effect on neurite extension; stimulation of D3 and D4 receptors increased the branching and extension of neurites. Similar results were found for primary mesencephalic cultures stimulated with quinpirole. These results suggest that the known D2-like receptors have specific developmental roles in regulating neuronal morphogenesis of dopaminergic pathways.
B C Swarzenski; L Tang; Y J Oh; K L O'Malley; R D Todd
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  91     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-02-22     Completed Date:  1994-02-22     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  649-53     Citation Subset:  IM    
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110.
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MeSH Terms
Cell Line
Dopamine Agents / pharmacology
Ergolines / pharmacology
Mesencephalon / cytology,  drug effects
Neurites / metabolism
Neurons / drug effects,  metabolism*,  ultrastructure
Receptors, Dopamine / genetics,  metabolism*
Receptors, Dopamine D2 / genetics,  metabolism*
Receptors, Dopamine D3
Receptors, Dopamine D4
Salicylamides / pharmacology
Grant Support
Reg. No./Substance:
0/DRD3 protein, human; 0/DRD4 protein, human; 0/Dopamine Agents; 0/Drd3 protein, rat; 0/Drd4 protein, rat; 0/Ergolines; 0/Receptors, Dopamine; 0/Receptors, Dopamine D2; 0/Receptors, Dopamine D3; 0/Salicylamides; 137750-34-6/Receptors, Dopamine D4; 84226-12-0/eticlopride; 85760-74-3/Quinpirole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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