Document Detail

Morphogenesis and pathogenesis of chronic lung diseases. VIII. Cellularization of lung interlobular areas as a preliminary phase of peribronchovascular fibrosis.
MedLine Citation:
PMID:  772786     Owner:  NLM     Status:  MEDLINE    
An experimental investigation of the lung interlobular areas was performed by elicitation of rabbits with antigens (aspergillar and human-serum proteins) administered in aerosols or intramuscularly in Freund's adjuvant. The cell accumulations in the interlobular areas developed irrespective of the antigen, duration of exposure and route of administration. The cells accumulated (reticulo-lymphoid, plasma cells, eosinocytes) were counted and the areal surface measured. The total cell count and the proportion of plasma cells appeared to be related to time, dose and antigenicity of the proteins administered. Fibrillogenesis was also observed between cells in the interlobular areas during prolonged administration of antigens, pointing out the importance of the interlobular lesions in chronic lung processes.
A Eskenasy; D Marinescu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Médecine interne     Volume:  14     ISSN:  0377-1202     ISO Abbreviation:  Med Interne     Publication Date:    1976 Jan-Mar
Date Detail:
Created Date:  1976-07-06     Completed Date:  1976-07-06     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7506353     Medline TA:  Med Interne     Country:  ROMANIA    
Other Details:
Languages:  eng     Pagination:  39-45     Citation Subset:  IM    
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MeSH Terms
Antigens, Fungal
Aspergillus fumigatus / immunology
Blood Vessels / pathology
Chronic Disease
Freund's Adjuvant
Lung / pathology*
Lung Diseases / immunology,  pathology*
Pulmonary Alveoli / pathology
Pulmonary Fibrosis / pathology
Respiratory Hypersensitivity / pathology*
Reg. No./Substance:
0/Antigens, Fungal; 9007-81-2/Freund's Adjuvant

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