| Morphogenesis and histostereological analysis of hepatopathy induced by cyclophosphamide. | |
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MedLine Citation:
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PMID: 21113471 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Characteristics and regularities of structural reorganization of the liver in experimental cyclophosphamide hepatopathy were studied. Single injection of the drug caused pronounced morphofunctional changes in the liver (small focal hepatocyte necroses mainly in the periportal zone, mononuclear cell infiltration developing in the presence of circulatory disorders). The key event in the spatial reorganization of the liver after cyclophosphamide injection is reduction of hepatocyte volume density, increase of their surface density and surface/volume ratio. The percentage of binuclear hepatocytes increases in the liver early after cyclophosphamide injection; later the percentage of mononuclear cells increases. Other important changes in the spatial reorganization of the liver under the effect of cyclophosphamide are the increase in the volume and surface densities of sinusoids. These changes develop as a result of augmenting vascular plethora and blood cell stasis with the development of thrombosis during later periods. |
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Authors:
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L M Nepomnyashchikh; O P Molodykh; E L Lushnikova; Yu A Sorokina |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Bulletin of experimental biology and medicine Volume: 149 ISSN: 1573-8221 ISO Abbreviation: Bull. Exp. Biol. Med. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-11-29 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372557 Medline TA: Bull Exp Biol Med Country: United States |
Other Details:
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Languages: eng; rus Pagination: 104-12 Citation Subset: IM |
Affiliation:
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Department of Pathology and Pathomorphology, Institute of Regional Pathology and Pathomorphology, Siberian Division of Russian Academy of Medical Sciences, Novosibirsk, Russia. pathol@soramn.ru |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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