| Morphogenesis and cell cycle progression in Candida albicans. | |
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MedLine Citation:
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PMID: 17055773 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Candida albicans, an opportunistic human pathogen, displays three modes of growth: yeast, pseudohyphae and true hyphae, all of which differ both in morphology and in aspects of cell cycle progression. In particular, in hyphal cells, polarized growth becomes uncoupled from other cell cycle events. Yeast or pseudohyphae that undergo a cell cycle delay also exhibit polarized growth, independent of cell cycle progression. The Spitzenkörper, an organelle composed of vesicles associated with hyphal tips, directs continuous hyphal elongation in filamentous fungal species and also in C. albicans hyphae. A polarisome mediates cell cycle dependent growth in yeast and pseudohyphae. Regulation of morphogenesis and cell cycle progression is dependent upon specific cyclins, all of which affect morphogenesis and some of which function specifically in yeast or hyphal cells. Future work will probably focus on the cell cycle checkpoints involved in connecting morphogenesis to cell cycle progression. |
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Authors:
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Judith Berman |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Review Date: 2006-10-20 |
Journal Detail:
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Title: Current opinion in microbiology Volume: 9 ISSN: 1369-5274 ISO Abbreviation: Curr. Opin. Microbiol. Publication Date: 2006 Dec |
Date Detail:
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Created Date: 2006-11-27 Completed Date: 2007-03-02 Revised Date: 2011-01-10 |
Medline Journal Info:
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Nlm Unique ID: 9815056 Medline TA: Curr Opin Microbiol Country: England |
Other Details:
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Languages: eng Pagination: 595-601 Citation Subset: IM |
Affiliation:
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Department of Genetics, Cell Biology and Development, 6-160 Jackson Hall, 321 Church Street SE, University of Minnesota, Minneapolis, MN 55455, USA. jberman@umn.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Candida albicans
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cytology*,
growth & development Cell Cycle / physiology Cell Cycle Proteins / physiology* Cell Polarity / physiology* Gene Expression Regulation, Fungal Hyphae / growth & development* Morphogenesis Protein Kinases / chemistry, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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P41 RR011823-090123/RR/NCRR NIH HHS; P41 RR011823-100123/RR/NCRR NIH HHS; R01 AI/DE14666/AI/NIAID NIH HHS; R01 DE014666-01A1/DE/NIDCR NIH HHS; R01 DE014666-02/DE/NIDCR NIH HHS; R01 DE014666-03/DE/NIDCR NIH HHS; R01 DE014666-04/DE/NIDCR NIH HHS; R01 DE014666-05/DE/NIDCR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cell Cycle Proteins; EC 2.7.-/Protein Kinases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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