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Morphogenesis can be driven by properly parametrised mechanical feedback.
MedLine Citation:
PMID:  24264054     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
A fundamental problem of morphogenesis is whether it presents itself as a succession of links that are each driven by its own specific cause-effect relationship, or whether all of the links can be embraced by a common law that is possible to formulate in physical terms. We suggest that a common biophysical background for most, if not all, morphogenetic processes is based upon feedback between mechanical stresses (MS) that are imposed to a given part of a developing embryo by its other parts and MS that are actively generated within that part. The latter are directed toward hyper-restoration (restoration with an overshoot) of the initial MS values. We show that under mechanical constraints imposed by other parts, these tendencies drive forth development. To provide specificity for morphogenetic reactions, this feedback should be modulated by long-term parameters and/or initial conditions that are set up by genetic factors. The experimental and model data related to this concept are reviewed.
Authors:
L V Beloussov
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-25
Journal Detail:
Title:  The European physical journal. E, Soft matter     Volume:  36     ISSN:  1292-895X     ISO Abbreviation:  Eur Phys J E Soft Matter     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101126530     Medline TA:  Eur Phys J E Soft Matter     Country:  -    
Other Details:
Languages:  ENG     Pagination:  9946     Citation Subset:  -    
Affiliation:
Laboratory of Developmental Biophysics, Faculty of Biology, Moscow State University, 119992, Moscow, Russia, morphogenesis@yandex.ru.
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