| Morphine-theophylline interaction: antagonism or facilitation? | |
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MedLine Citation:
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PMID: 7272590 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1 Morphine-theophylline interactions were investigated in both acute and narcotic-dependent preparations, in vitro and in vivo, using four different experimental models: LD50 doses of morphine and naloxone in the mouse; naloxone-induced contractions in the electrically-stimulated and opiate-dependent isolated ileum of the guinea-pig; naloxone-induced jumps in the mouse; an calcium uptake in synaptosomal preparations. 2 The LD50 of morphine was significantly increased by theophylline. 3 The lethal effect of theophylline was potentiated by pretreatment of the animals with naloxone. 4 Theophylline displayed protective effects in the inhibitory response to morphine and antagonism to the withdrawal response induced by naloxone in the electrically-stimulated isolated ileum of the guinea-pig. 5 The number of jumps induced by naloxone in morphine-dependent mice was significantly diminished by theophylline. 6 The inhibitory effect of morphine on the synaptosomal uptake of calcium was decreased by theophylline. 7 The effects of both morphine and theophylline on the cyclic nucleotides and the possible role of calcium in these actions are discussed. |
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Authors:
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S Brailowsky; F Guerrero-Muñoz; M Luján; M Shkurovich |
Publication Detail:
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Type: In Vitro; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 73 ISSN: 0007-1188 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 1981 Aug |
Date Detail:
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Created Date: 1981-11-18 Completed Date: 1981-11-18 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 887-92 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Calcium / metabolism Drug Interactions Electric Stimulation Guinea Pigs Ileum / drug effects Lethal Dose 50 Mice Morphine / pharmacology* Motor Activity / drug effects Naloxone / pharmacology Synaptosomes / metabolism Theophylline / pharmacology* |
| Chemical | |
Reg. No./Substance:
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465-65-6/Naloxone; 57-27-2/Morphine; 58-55-9/Theophylline; 7440-70-2/Calcium |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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