Document Detail

Morphine-theophylline interaction: antagonism or facilitation?
MedLine Citation:
PMID:  7272590     Owner:  NLM     Status:  MEDLINE    
1 Morphine-theophylline interactions were investigated in both acute and narcotic-dependent preparations, in vitro and in vivo, using four different experimental models: LD50 doses of morphine and naloxone in the mouse; naloxone-induced contractions in the electrically-stimulated and opiate-dependent isolated ileum of the guinea-pig; naloxone-induced jumps in the mouse; an calcium uptake in synaptosomal preparations. 2 The LD50 of morphine was significantly increased by theophylline. 3 The lethal effect of theophylline was potentiated by pretreatment of the animals with naloxone. 4 Theophylline displayed protective effects in the inhibitory response to morphine and antagonism to the withdrawal response induced by naloxone in the electrically-stimulated isolated ileum of the guinea-pig. 5 The number of jumps induced by naloxone in morphine-dependent mice was significantly diminished by theophylline. 6 The inhibitory effect of morphine on the synaptosomal uptake of calcium was decreased by theophylline. 7 The effects of both morphine and theophylline on the cyclic nucleotides and the possible role of calcium in these actions are discussed.
S Brailowsky; F Guerrero-Muñoz; M Luján; M Shkurovich
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  British journal of pharmacology     Volume:  73     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1981 Aug 
Date Detail:
Created Date:  1981-11-18     Completed Date:  1981-11-18     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  887-92     Citation Subset:  IM    
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MeSH Terms
Calcium / metabolism
Drug Interactions
Electric Stimulation
Guinea Pigs
Ileum / drug effects
Lethal Dose 50
Morphine / pharmacology*
Motor Activity / drug effects
Naloxone / pharmacology
Synaptosomes / metabolism
Theophylline / pharmacology*
Reg. No./Substance:
465-65-6/Naloxone; 57-27-2/Morphine; 58-55-9/Theophylline; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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