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Morphine preconditioning, cardioprotection and left ventricular remodelling in rabbits.
MedLine Citation:
PMID:  21744704     Owner:  NLM     Status:  In-Process    
OBJECTIVE: The objective of this study was to investigate, in a rabbit model, the cardioprotective effect of morphine preconditioning against cardiac remodelling.
METHODS AND RESULTS: In male New Zealand rabbits myocardial I/R injury was established by ligating the left descending coronary artery followed by perfusion. The rabbits were randomly divided into: (i) a normal saline sham group (S), (ii) a morphine sham group (MS), (iii) a normal saline group (NS); (iv) a morphine preconditioning group (MPC). After I/R injury, cardiac function was evaluated by echocardiography and biologic markers at day 1, day 3, day 7, day 14, day 21 and day 28. At day 1 after I/R injury, in comparison to the NS group, morphine preconditioning: (i) significantly improved haemodynamic parameters; (ii) reduced myocardial infarct size; (iii) lowered troponin I level. At day 28 after I/R injury, the concentration of B-type natriuretic peptide was significantly lower in the MPC group compared to the NS group. The MPC group had heavier left ventricles than the MS group while the NS group had heavier right ventricles than the other groups, respectively. Furthermore, the MPC group showed improved haemodynamic parameters. Echocardiography showed a higher left ventricular ejection fraction and fractional shorting in the MPC group compared to the NS group at each observation point.
CONCLUSION: After I/R injury and morphine preconditioning by a single dose, we have observed a prolonged cardioprotective effect and an improved cardiac function. Morphine preconditioning may reduce post-infarction remodelling.
Chengxiao Liu; Ruping Dai; Rong Yu; Junmei Xu
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta cardiologica     Volume:  66     ISSN:  0001-5385     ISO Abbreviation:  Acta Cardiol     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-07-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370570     Medline TA:  Acta Cardiol     Country:  Belgium    
Other Details:
Languages:  eng     Pagination:  341-8     Citation Subset:  IM    
Department of Anaesthesiology, Xiang-Ya Second Hospital, Xiang-Ya Medical College, Central South University, Changsha, Hunan, China.
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