| Morphine potentiates dextromethorphan-induced vasodilation in rat superior mesenteric artery. | |
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MedLine Citation:
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PMID: 14751409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The combined action of morphine and dextromethorphan on the superior mesenteric artery was investigated in this study. The artery was cut into rings, placed in a muscle bath and mounted to a force transducer for recording tension. Rings preconstricted with 1 microM phenylephrine produced a dose-dependent relaxation to graded doses of dextromethorphan but showed no response to morphine. An equimolar combination of morphine and dextromethorphan exhibited a marked synergism quantitated by a factor of 3.7 (1.8-7.7, 95% CI). Naloxone, which had no effect on the dextromethorphan dose-response relation, abolished the synergism. Removal of the endothelium produced a slight attenuation of the morphine-dextromethorphan synergism, but the magnitude of this attenuation was the same when dextromethorphan alone was examined in the denuded preparation. In contrast to the marked synergism seen in the mesenteric artery preparation, similar experiments on the carotid artery and the aorta produced only additive interactions. |
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Authors:
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Saadet Inan; Ronald J Tallarida |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: European journal of pharmacology Volume: 486 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 2004 Feb |
Date Detail:
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Created Date: 2004-01-30 Completed Date: 2004-09-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 61-5 Citation Subset: IM |
Affiliation:
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Department of Pharmacology and Center for Substance Abuse Research, Temple University School of Medicine, 3420 N. Broad St., Philadelphia, PA 19140, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dextromethorphan / pharmacology* Dose-Response Relationship, Drug Drug Synergism Male Mesenteric Artery, Superior / drug effects*, physiology Morphine / pharmacology* Rats Rats, Sprague-Dawley Vasodilation / drug effects*, physiology |
| Grant Support | |
ID/Acronym/Agency:
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DA 09793-06/DA/NIDA NIH HHS; DA 13429/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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125-71-3/Dextromethorphan; 57-27-2/Morphine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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