| Morphine-induced postconditioning modulates mitochondrial permeability transition pore opening via delta-1 opioid receptors activation in isolated rat hearts. | |
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MedLine Citation:
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PMID: 21860754 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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BACKGROUND: It is generally accepted that morphine affords cardioprotection against ischemia/reperfusion injury. Inhibition of the mitochondrial permeability transition pore (MPTP) is considered an end target for cardioprotection. The aim of this study was to investigate the involvement of opioid receptors (OR) and MPTP in morphine-induced postconditioning (M-Post). METHODS: Isolated rat hearts were subjected to 30 min of regional ischemia and 2 h of reperfusion. Hearts were treated with 1 µM morphine, with or without the OR antagonists or a MPTP opener at early reperfusion. Infarct size was measured with 2,3,5-triphenyltetrazolium chloride staining. RESULTS: There were no significant differences in cardiodynamic variables except a decrease in heart rate in the M-Post group (P < 0.01 vs. control) after reperfusion. M-Post dramatically reduced infarct-risk volume ratio (9.8 ± 2.5%, P < 0.001 vs. 30.0 ± 3.7% in control). This beneficial effect on infarct volume by M-Post was comparable with ischemic postconditioning (11.9 ± 2.2%, P > 0.05). The nonspecific OR antagonist naloxone (25.7 ± 1.9%, P < 0.01), the δ-OR antagonist naltrindole (27.8 ± 4.3%, P < 0.05) and δ(1)-OR antagonist 7-benzylidenenaltrexone (24.7 ± 3.7%, P < 0.01) totally abrogated the anti-infarct effect of M-Post. In addition, the anti-infarct effect by M-Post was also totally blocked by the MPTP opener atractyloside (26.3 ± 5.2%, P < 0.05). CONCLUSIONS: M-Post effectively reduces myocardial infarction. The anti-infarct effect by M-Post is mediated via activation of δ-OR, especially δ(1)-OR, and inhibition of the MPTP opening. |
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Authors:
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June Hong Kim; Kook Jin Chun; Yong Hyun Park; Jun Kim; Jeong Su Kim; Young Ho Jang; Mi Young Lee; Jae Hong Park |
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Publication Detail:
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Type: Journal Article Date: 2011-07-17 |
Journal Detail:
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Title: Korean journal of anesthesiology Volume: 61 ISSN: 2005-7563 ISO Abbreviation: Korean J Anesthesiol Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-08-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101502451 Medline TA: Korean J Anesthesiol Country: Korea (South) |
Other Details:
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Languages: eng Pagination: 69-74 Citation Subset: - |
Affiliation:
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Institute of Cardiovascular Research, Pusan National University Yangsan Hospital, Yangsan, Korea. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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