Document Detail


Morphine-induced changes in cerebral and cerebellar nitric oxide synthase activity.
MedLine Citation:
PMID:  8846816     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of acute and chronic morphine treatment on nitric oxide (NO) synthase activity (determined by the rate of conversion of [14C]arginine into [14C]citrulline) on mouse brain was studied. Acute morphine treatment induced an increased in Ca2+ -dependent NO synthase in cerebellum. This effect was blocked by coadministration with naloxone. Chronic morphine treatment (by s.c. pellet) also produced an increase in cerebellar NO synthase, with a maximum on the second day of implantation. No significant changes were found in frontal cortex and forebrain during acute or chronic morphine treatment. The relationship between opiate effects and the L-arginine: NO pathway is discussed.
Authors:
J C Leza; I Lizasoain; O San-Martín-Clark; P Lorenzo
Related Documents :
18986766 - Inhibition of the ubiquitin-proteasome activity prevents glutamate transporter degradat...
8395406 - Effects of the selective kappa-opioid agonist u50,488 upon the electrical activity of s...
11832216 - Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomeriz...
202986 - Time-dependent disruptive effects of apomorphine and alpha-methyl-p-tyrosine on develop...
19375896 - Anti-inflammatory and antimicrobial effects of garlic and synergistic effect between ga...
20546876 - Oxybutynin and propiverine suppress adenosine triphosphate-induced bladder overactivity...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  285     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-10-21     Completed Date:  1996-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Affiliation:
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Calcium / physiology
Cerebellum / drug effects*,  enzymology
Cerebral Cortex / drug effects*,  enzymology
Male
Mice
Morphine / pharmacology*
Naloxone / pharmacology
Narcotics / pharmacology*
Nitric Oxide Synthase / metabolism*
Prosencephalon / drug effects*,  enzymology
Chemical
Reg. No./Substance:
0/Narcotics; 465-65-6/Naloxone; 57-27-2/Morphine; 7440-70-2/Calcium; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Endothelin ETA receptors mediate human uterine smooth muscle contraction.
Next Document:  GABAB receptor antagonist CGP 35348 shortens transcallosal response latency of pyramidal tract neuro...