Document Detail

Morphine-induced changes in cerebral and cerebellar nitric oxide synthase activity.
MedLine Citation:
PMID:  8846816     Owner:  NLM     Status:  MEDLINE    
The effect of acute and chronic morphine treatment on nitric oxide (NO) synthase activity (determined by the rate of conversion of [14C]arginine into [14C]citrulline) on mouse brain was studied. Acute morphine treatment induced an increased in Ca2+ -dependent NO synthase in cerebellum. This effect was blocked by coadministration with naloxone. Chronic morphine treatment (by s.c. pellet) also produced an increase in cerebellar NO synthase, with a maximum on the second day of implantation. No significant changes were found in frontal cortex and forebrain during acute or chronic morphine treatment. The relationship between opiate effects and the L-arginine: NO pathway is discussed.
J C Leza; I Lizasoain; O San-Martín-Clark; P Lorenzo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of pharmacology     Volume:  285     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1995 Oct 
Date Detail:
Created Date:  1996-10-21     Completed Date:  1996-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Departamento de Farmacología, Facultad de Medicina, Universidad Complutense de Madrid, Spain.
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MeSH Terms
Calcium / physiology
Cerebellum / drug effects*,  enzymology
Cerebral Cortex / drug effects*,  enzymology
Morphine / pharmacology*
Naloxone / pharmacology
Narcotics / pharmacology*
Nitric Oxide Synthase / metabolism*
Prosencephalon / drug effects*,  enzymology
Reg. No./Substance:
0/Narcotics; 465-65-6/Naloxone; 57-27-2/Morphine; 7440-70-2/Calcium; EC Oxide Synthase

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