| Morphine-induced changes in acetylcholine release in the interpeduncular nucleus and relationship to changes in motor behavior in rats. | |
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MedLine Citation:
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PMID: 17544456 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Owing to multiple anatomical connections and functional interactions between the habenulo-interpeduncular and the mesolimbic pathways, it has been proposed that these systems could together mediate the reinforcing properties of addictive drugs. 18-Methoxycoronaridine, an agent that reduces morphine self-administration and attenuates dopamine sensitization in the nucleus accumbens in response to repeated morphine, has been shown to produce these effects by acting in the medial habenula and interpeduncular nucleus. Acetylcholine, one of the predominant neurotransmitters in the interpeduncular nucleus, may be a major determinant of these interactions. To determine if and how morphine acts in the interpeduncular nucleus, the effects of acute and repeated administration of morphine on extracellular acetylcholine levels in this brain area were assessed. In addition, the motor behavior of rats receiving repeated morphine administration was monitored during microdialysis sessions. Acutely, morphine produced a biphasic effect on extracellular acetylcholine levels in the interpeduncular nucleus such that low and high doses of morphine (i.e., 5 and 20mg/kg i.p.) significantly increased and decreased acetylcholine levels, respectively. Repeated administration of the same doses of morphine resulted in tolerance to the inhibitory but not to the stimulatory effects; tolerance was accompanied by sensitization to morphine-induced changes in locomotor activity and stereotypic behavior. The latter results suggest that tolerance to morphine's effect on the cholinergic habenulo-interpeduncular pathway is related to its sensitizing effects on the mesostriatal dopaminergic pathways. |
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Authors:
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Olga D Taraschenko; Heather Y Rubbinaccio; Joseph M Shulan; Stanley D Glick; Isabelle M Maisonneuve |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2007-04-29 |
Journal Detail:
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Title: Neuropharmacology Volume: 53 ISSN: 0028-3908 ISO Abbreviation: Neuropharmacology Publication Date: 2007 Jul |
Date Detail:
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Created Date: 2007-08-03 Completed Date: 2007-11-09 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0236217 Medline TA: Neuropharmacology Country: England |
Other Details:
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Languages: eng Pagination: 18-26 Citation Subset: IM |
Affiliation:
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Center for Neuropharmacology and Neuroscience, Albany Medical College, 47 New Scotland Avenue, Albany, NY 12208, USA. tarasco@mail.amc.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylcholine
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metabolism* Analysis of Variance Animals Behavior, Animal / drug effects* Chromatography, High Pressure Liquid / methods Dose-Response Relationship, Drug Drug Administration Schedule Female Grooming / drug effects Microdialysis / methods Morphine / administration & dosage* Motor Activity / drug effects Narcotics / administration & dosage* Pedunculopontine Tegmental Nucleus / drug effects* Rats Rats, Sprague-Dawley Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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DA 016283/DA/NIDA NIH HHS; R01 DA016283-04/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Narcotics; 51-84-3/Acetylcholine; 57-27-2/Morphine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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