Document Detail


Morphine in tardive and idiopathic dystonia (short communication).
MedLine Citation:
PMID:  11716139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Opioids have been shown to improve L-Dopa induced dyskinesias in patients with Parkinson's disease. In this pilot trial of five patients with tardive and four patients with idiopathic dystonia we tested the effect of morphinsulfate in a retarded form with a dosage of 20-60 mg per day. A substantial improvement of dystonic movements could be observed in four patients with tardive and one patient with idiopathic dystonia. The effect was only transient in tardive dystonia while pain relief mediated by morphine overlasted the effect on involuntary movements.
Authors:
D Berg; G Becker; M Naumann; K Reiners
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  108     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  2001  
Date Detail:
Created Date:  2001-11-21     Completed Date:  2002-04-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  Austria    
Other Details:
Languages:  eng     Pagination:  1035-41     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Würzburg, Federal Republic of Germany. daniela.berg@mail.uni-wuerzburg.de
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Dose-Response Relationship, Drug
Dyskinesia, Drug-Induced / drug therapy*,  physiopathology
Dystonia / drug therapy*,  physiopathology
Female
Humans
Levodopa / adverse effects*
Middle Aged
Morphine / adverse effects,  therapeutic use*
Neostriatum / drug effects,  metabolism,  physiopathology
Pain / drug therapy*,  etiology,  physiopathology
Parkinson Disease / drug therapy*,  physiopathology
Pilot Projects
Receptors, Dopamine / drug effects,  metabolism
Treatment Outcome
Chemical
Reg. No./Substance:
0/Levodopa; 0/Receptors, Dopamine; 57-27-2/Morphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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