Document Detail

Morphine hyperthermia in rats: role of neurochemical substances in brain.
MedLine Citation:
PMID:  7298148     Owner:  NLM     Status:  MEDLINE    
Central neurochemical mechanism underlying the hyperthermic effect of morphine has been investigated in rats. 200 micrograms morphine hydrochloride, when administered through cerebroventricular route at different seasonal air temperature, caused a rise in rectal temperature of rats. This hyperthermia was not affected by prior administration of antiserotonergic (pCPA, 5.6-DHT) or anticatecholaminergic (PBZ, 6-OHDA) drugs, as well as by PGE synthetase inhibitor, indomethacin. Similarity, cholinergic muscarinic or nicotinic receptor blockers, such as atropine and pentolinium/ D-tubocurarine respectively, were ineffective to modify it. Whereas, the depletion of acetylcholine in brain by pretreating the animals with hemicholinium profoundly delayed the hyperthermia, suggesting a central cholinergic involvement in morphine induced hyperthermia in rats.
U Prakash; P K Dey
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Indian journal of physiology and pharmacology     Volume:  25     ISSN:  0019-5499     ISO Abbreviation:  Indian J. Physiol. Pharmacol.     Publication Date:    1981 Jul-Sep
Date Detail:
Created Date:  1982-01-28     Completed Date:  1982-01-28     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0374707     Medline TA:  Indian J Physiol Pharmacol     Country:  INDIA    
Other Details:
Languages:  eng     Pagination:  237-45     Citation Subset:  IM    
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MeSH Terms
Body Temperature / drug effects*
Brain Chemistry / drug effects*
Catecholamines / physiology
Injections, Intraventricular
Morphine / pharmacology*
Parasympatholytics / pharmacology
Prostaglandin Antagonists / pharmacology
Serotonin Antagonists / pharmacology
Reg. No./Substance:
0/Catecholamines; 0/Parasympatholytics; 0/Prostaglandin Antagonists; 0/Serotonin Antagonists; 57-27-2/Morphine

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